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tyrocidine D


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  • Norine ID: NOR00301
  • Family: tyrocidine
  • Synonym(s): tyrocidine D;
  • Activity: antibiotic
  • Class: peptide
  • Formula: C72H90N16O12
  • Monoisotopic mass: 1370.692412424 g/mol
  • Comment: Tyrocidine kills bacteria by interacting with their cytoplasmic membrane and causing leakage of their intracellular content. It also affects intracellular membranes such as those of mitochondria.
  • Source: norine
  • Entry information:
    • status: curated
    • last modification date: 2006-07-27
      Norine team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Univeristy of Lille, France, Charles Viollette Institute, ProBioGEM team, Lille, France]
    • view all entry history
  • Type: cyclic
  • Number of monomers: 10
  • Smiles: CC(C)C[C@H]1C(=O)N[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CCCN)C(C)C)CC3=CNC4=CC=CC=C43)CCC(=O)N)CC(=O)N)CC5=CNC6=CC=CC=C65)CC7=CNC8=CC=CC=C87)CC9=CC=CC=C9

  • Smiles2Monomer  Run Smiles2Monomers to infer graph

  • Monomeric composition :
    1
    D-Phe
    2
    Pro
    3
    Trp
    4
    D-Trp
    5
    Asn
    6
    Gln
    7
    Trp
    8
    Val
    9
    Orn
    10
    Leu
  • Graph representation: D-Phe,Pro,Trp,D-Trp,Asn,Gln,Trp,Val,Orn,Leu @1,9 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @0,8

  • Atomic structure:
    Chemical structure
  • Bacillus brevis
  • gram: positive
  • synonyms: Brevibacillus brevis
  • taxid: 1393 (view NCBI taxonomy browser)

  • Links between organisms producing the tyrocidine D: Bacillus brevis
  • The tyrocidine biosynthesis operon of Bacillus brevis: complete nucleotide sequence and biochemical characterization of functional internal adenylation domains
    Mootz HD, Marahiel MA, Journal of bacteriology , 1997, Nov,179(21):6843-50.
    pubMed: 9352938


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