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antiamoebin I


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  • Norine ID: NOR00945
  • Family: antiamoebin
  • Synonym(s): antiamoebin I;
  • Activity: antibiotic
  • Class: peptaibol
  • Formula: C80H123N17O20
  • Monoisotopic mass: 1641.913029461 g/mol
  • Source: norine
  • Entry information:
  • Type: linear
  • Number of monomers: 16
  • Smiles: CCC(C)(NC(=O)C(C)(C)NC(=O)C(C)(C)NC(=O)C(C)(C)NC(=O)C(Cc1ccccc1)NC(C)=O)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(C)(C)C(=O)NC(C)(C)C(=O)N5CC(O)CC5(C(=O)NC(CCC(N)=O)C(=O)NC(C)(CC)C(=O)N4CC(O)CC4(C(=O)NC(C)(C)C(=O)N3CCCC3(C(=O)NC(CO)Cc2ccccc2)))

  • Smiles2Monomer  Run Smiles2Monomers to infer graph

  • Monomeric composition and PDB SEQRES:
    gra
    1
    Ac-Phe
    1 2
    ACE PHE
    2
    Aib
    3
    AIB
    3
    Aib
    4
    AIB
    4
    Aib
    5
    AIB
    5
    D-Ival
    6
    DIV
    6
    Gly
    7
    GLY
    7
    Leu
    8
    LEU
    8
    Aib
    9
    AIB
    9
    Aib
    10
    AIB
    10
    4OH-Pro
    11
    HYP
    11
    Gln
    12
    GLN
    12
    D-Ival
    13
    DIV
    13
    4OH-Pro
    14
    HYP
    14
    Aib
    15
    AIB
    15
    Pro
    16
    PRO
    16
    Pheol
    17
    PHL
  • Graph representation: Ac-Phe,Aib,Aib,Aib,D-Ival,Gly,Leu,Aib,Aib,4OH-Pro,Gln,D-Ival,4OH-Pro,Aib,Pro,Pheol @1 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @8,10 @9,11 @10,12 @11,13 @12,14 @13,15 @14

  • Atomic structure:
    Chemical structure
  • Stilbella fimetaria
  • synonyms: Stilbella erythrocephala
  • taxid: 327576 (view NCBI taxonomy browser)

  • Gliocladium catenulatum
  • synonyms: Clonostachys rosea f. catenulata
  • taxid: 62888 (view NCBI taxonomy browser)

  • Emericellopsis salmosynnemata
  • taxid: 118885 (view NCBI taxonomy browser)

  • Emericellopsis synnematicola
  • taxid: 281372 (view NCBI taxonomy browser)

  • Emericellopsis poonensis

  • Links between organisms producing the antiamoebin I: Stilbella fimetaria, Gliocladium catenulatum, Emericellopsis salmosynnemata, Emericellopsis synnematicola, Emericellopsis poonensis
  • New sequences and new fungal producers of peptaibol antibiotics antiamoebins
    Jaworski A, Bruckner H, Journal of peptide science , 2000, Apr,6(4):149-67.
    pubMed: 10809388
  • Studies on the secondary structure of the peptide antibiotic antiamoebin I
    Krishnaswamy S, Pattabhi V, Indian journal of biochemistry and biophysics , 1987, Feb,24(1):1-5.
    pubMed: 3623592


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