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cephaibol A


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  • Norine ID: NOR00969
  • Family: cephaibol
  • Synonym(s): cephaibol A;
  • Activity: antibiotic
  • Class: peptaibol
  • Formula: C82H127N17O20
  • Monoisotopic mass: 1669.9443295889998 g/mol
  • Comment: The striking biological property of cephaibol A is its pronounced anthelmintic action and activity against ectoparasites.
  • Source: norine
  • Entry information:
  • Type: linear
  • Number of monomers: 16
  • Smiles: CC[C@@](C)(C(=O)NC(C)(C)C(=O)N1CC(C[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@](C)(CC)C(=O)N2CC(C[C@H]2C(=O)NC(C)(C)C(=O)N3CCC[C@H]3C(=O)NC(CC4=CC=CC=C4)CO)O)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)C(C)(C)NC(=O)C(C)(C)NC(=O)C(C)(C)NC(=O)C(C)(C)NC(=O)[C@H](CC5=CC=CC=C5)NC(=O)C

  • Smiles2Monomer  Run Smiles2Monomers to infer graph

  • Monomeric composition and PDB SEQRES:
    gra
    1
    Ac-Phe
    1 2
    ACE PHE
    2
    Aib
    3
    AIB
    3
    Aib
    4
    AIB
    4
    Aib
    5
    AIB
    5
    Aib
    6
    AIB
    6
    Gly
    7
    GLY
    7
    Leu
    8
    LEU
    8
    D-Ival
    9
    DIV
    9
    Aib
    10
    AIB
    10
    4OH-Pro
    11
    HYP
    11
    Gln
    12
    GLN
    12
    D-Ival
    13
    DIV
    13
    4OH-Pro
    14
    HYP
    14
    Aib
    15
    AIB
    15
    Pro
    16
    PRO
    16
    Pheol
    17
    PHL
  • Graph representation: Ac-Phe,Aib,Aib,Aib,Aib,Gly,Leu,D-Ival,Aib,4OH-Pro,Gln,D-Ival,4OH-Pro,Aib,Pro,Pheol @1 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @8,10 @9,11 @10,12 @11,13 @12,14 @13,15 @14

  • Atomic structure:
    Chemical structure
  • Acremonium tubakii
  • taxid: 146077 (view NCBI taxonomy browser)

  • Links between organisms producing the cephaibol A: Acremonium tubakii
  • Cephaibols, new peptaibol antibiotics with anthelmintic properties from Acremonium tubakii DSM 12774
    Kim JH, Schiell M, Hofmann J, Kurz M, Schmidt FR, Vogel M, Wink J, Seibert G, The Journal of antibiotics , 2001, Mar,54(3):220-33.
    pubMed: 11372779


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