Norine

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prolylfk506


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  • Norine ID: NOR01906
  • Family: unknown
  • Synonym(s):
  • Activity:
  • Class:
  • Monoisotopic mass: 804.01816 g/mol
  • Source: StreptomeDB
  • Contributor (creation): Norine Bot [CRIStAL (UMR CNRS 9189), ex-LIFL, France]
  • Entry information:
  • Type:
  • Smiles: C=CC[C@@H]1/C=C(/C)\C[C@H](C)C[C@H](OC)[C@H]2O[C@](O)([C@@H](C[C@@H]2OC)C)C(=O)C(=O)N2[C@H](C(=O)O[C@@H]([C@@H]([C@H](CC1=O)O)C)/C(=C/[C@@H]1CC[C@H]([C@@H](C1)OC)O)/C)CCCC2

  • Graph inference:



  • Atomic structure:
  • Chemical structure
    rBAN vizualisation:
  • Links between organisms producing the prolylfk506:
  • Serum interleukin-6 levels as an indicator of acute rejection after liver transplantation in cynomologous monkeys.
    Surgery today , 1993, 23(6):521-7
    pubMed: 7689373
  • FK-506: a new immunosuppressive agent, failed to reduce cerebral vasospasm after experimental subarachnoid hemorrhage.
    The Journal of veterinary medical science , 1993, 55(4):581-6
    DOI: 10.1292/jvms.55.581
    pubMed: 7691190
  • The gamma-butyrolactone receptors BulR1 and BulR2 of Streptomyces tsukubaensis: tacrolimus (FK506) and butyrolactone synthetases production control.
    Applied microbiology and biotechnology , 2014, 98(11):4919-36
    DOI: 10.1007/s00253-014-5595-9
    pubMed: 24562179
  • Heterologous expression of natural product biosynthetic gene clusters in Streptomyces coelicolor: from genome mining to manipulation of biosynthetic pathways.
    Journal of industrial microbiology & biotechnology , 2014, 41(2):425-31
    DOI: 10.1007/s10295-013-1348-5
    pubMed: 24096958
  • Enhanced FK506 production in Streptomyces tsukubaensis by rational feeding strategies based on comparative metabolic profiling analysis.
    Biotechnology and bioengineering , 2013, 110(10):2717-30
    DOI: 10.1002/bit.24941
    pubMed: 23682004
  • Enhancement of FK506 production by engineering secondary pathways of Streptomyces tsukubaensis and exogenous feeding strategies.
    Journal of industrial microbiology & biotechnology , 2013, 40(9):1023-37
    DOI: 10.1007/s10295-013-1301-7
    pubMed: 23779221


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