Norine

home > NRP > norine

SANGLIFEHRIN A


Get HTML       

  • Norine ID: NOR01911
  • Family: unknown
  • Synonym(s):
  • Activity:
  • Class:
  • Monoisotopic mass: 1090.39024 g/mol
  • Source: StreptomeDB
  • Contributor (creation): Norine Bot [CRIStAL (UMR CNRS 9189), ex-LIFL, France]
  • Entry information:
  • Type:
  • Smiles: CC[C@H]1C[C@H](C)[C@@]2(NC1=O)O[C@@H](C[C@@H]([C@H](CC/C=C/C=C(/[C@@H]1C/C=C/C=C/[C@H](O)[C@H](C)[C@@H](O)[C@@H](CCC(=O)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N3NC(C(=O)O1)CCC3)Cc1cccc(c1)O)C(C)C)\C)C)O)[C@@H]([C@@H]([C@@H]2C)O)C

  • Graph inference:



  • Atomic structure:
  • Chemical structure
    rBAN vizualisation:
  • Streptomyces
  • gram: positive
  • taxid: 68187 (view NCBI taxonomy browser)

  • Links between organisms producing the SANGLIFEHRIN A: Streptomyces
  • Sanglifehrins A, B, C and D, novel cyclophilin-binding compounds isolated from Streptomyces sp. A92-308110. I. Taxonomy, fermentation, isolation and biological activity.
    The Journal of antibiotics , 1999, 52(5):466-73
    DOI: 10.7164/antibiotics.52.466
    pubMed: 10480570
  • Sanglifehrin-cyclophilin interaction: degradation work, synthetic macrocyclic analogues, X-ray crystal structure, and binding data.
    Journal of the American Chemical Society , 2003, 125(13):3849-59
    DOI: 10.1021/ja021327y
    pubMed: 12656618
  • Cloning, sequencing and characterization of the biosynthetic gene cluster of sanglifehrin A, a potent cyclophilin inhibitor.
    Molecular bioSystems , 2011, 7(3):852-61
    pubMed: 21416665
  • Sanglifehrins A, B, C and D, novel cyclophilin-binding compounds isolated from Streptomyces sp. A92-308110. II. Structure elucidation, stereochemistry and physico-chemical properties.
    The Journal of antibiotics , 1999, 52(5):474-9
    DOI: 10.7164/antibiotics.52.474
    pubMed: 10480571


back Return to annotations search