Norine

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DAPTOMYCIN


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  • Norine ID: NOR01919
  • Family: unknown
  • Synonym(s):
  • Activity: antimicrobial
  • Class:
  • Monoisotopic mass: 1620.67064 g/mol
  • Source: StreptomeDB
  • Contributor (creation): Norine Bot [CRIStAL (UMR CNRS 9189), ex-LIFL, France]
  • Entry information:
  • Type:
  • Smiles: NCCC[C@@H]1NC(=O)CNC(=O)C(NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc2c[nH]c3c2cccc3)NC(=O)CCCCCCCCC)CC(=O)N)CC(=O)O)C(C)OC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)CC(=O)O)C)CC(=O)O)CO)C(CC(=O)O)C)CC(=O)c1ccccc1N

  • Graph inference:



  • Atomic structure:
  • Chemical structure
    rBAN vizualisation:
  • Streptomyces roseosporus
  • gram: positive
  • synonyms: Streptomyces filamentosus,Streptomyces venezuelae subsp. roseospori,Streptomyces roseisporus
  • taxid: 67294 (view NCBI taxonomy browser)

  • Links between organisms producing the DAPTOMYCIN: Streptomyces roseosporus
  • Imaging mass spectrometry and genome mining via short sequence tagging identified the anti-infective agent arylomycin in Streptomyces roseosporus.
    Journal of the American Chemical Society , 2011, 133(45):18010-3
    DOI: 10.1021/ja2040877
    pubMed: 21999343
  • Stereospecific enzymatic transformation of alpha-ketoglutarate to (2S,3R)-3-methyl glutamate during acidic lipopeptide biosynthesis.
    Journal of the American Chemical Society , 2007, 129(39):12011-8
    DOI: 10.1021/ja074427i
    pubMed: 17784761
  • Strain improvement of Streptomyces roseosporus for daptomycin production by rational screening of He-Ne laser and NTG induced mutants and kinetic modeling.
    Applied biochemistry and biotechnology , 2011, 163(6):729-43
    DOI: 10.1007/s12010-010-9078-x
    pubMed: 20886375
  • Fatty acyl-AMP ligase involvement in the production of alkylresorcylic acid by a Myxococcus xanthus type III polyketide synthase.
    Chembiochem : a European journal of chemical biology , 2011, 12(14):2166-76
    DOI: 10.1002/cbic.201100344
    pubMed: 21815236
  • The lipopeptide antibiotic A54145 biosynthetic gene cluster from Streptomyces fradiae
    Baltz RH, Miao V, Brost R, Chapple J, She K, Gal MF, Journal of industrial microbiology and biotechnology , 2006, Feb,33(2):129-40. Epub 2005 Oct 6.
    DOI: 10.1007/s10295-005-0028-5
    pubMed: 16208464
  • Daptomycin biosynthesis in Streptomyces roseosporus: cloning and analysis of the gene cluster and revision of peptide stereochemistry
    Baltz RH, Miao V, Wrigley SK, Coeffet-Legal MF, Brian P, Brost R, Penn J, Whiting A, Martin S, Ford R, Parr I, Bouchard M, Silva CJ, Microbiology , 2005, May,151(Pt 5):1507-23.
    DOI: 10.1099/mic.0.27757-0
    pubMed: 15870461


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