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ACV


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  • Norine ID: NOR00006
  • DOI: 10.26097/nor00006
  • Family: ACV
  • Synonym(s): ACV;
  • Activity: antibiotic
  • Class: peptide
  • Formula: C14H25N3O6S
  • Monoisotopic mass: 363.14640624699996 g/mol
  • Comment: ACV is the penicillin and cephalosporin precursor.
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
    • status: curated
    • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
    • view all entry history
  • Type: linear
  • Number of monomers: 3
  • Smiles: CC(C)C(NC(=O)C(CS)NC(=O)CCCC(N)C(=O)O)C(=O)O

  • Graph inference:



  • Monomeric composition :
    1
    Aad
    2
    Cys
    3
    D-Val
  • Graph representation: Aad,Cys,D-Val @1 @0,2 @1

  • Atomic structure:
    Chemical structure
  • Penicillium chrysogenum
  • gram: n/a
  • synonyms: Penicillium notatum
  • taxid: 5076 (view NCBI taxonomy browser)

  • Acremonium chrysogenum
  • gram: n/a
  • synonyms: Cephalosporium acremonium
  • taxid: 5044 (view NCBI taxonomy browser)

  • Streptomyces clavuligerus
  • gram: positive
  • taxid: 1901 (view NCBI taxonomy browser)

  • Lysobacter lactamgenus
  • gram: positive
  • taxid: 39596 (view NCBI taxonomy browser)

  • Amycolatopsis lactamdurans
  • gram: positive
  • synonyms: Nocardia lactamdurans, Streptomyces lactamdurans
  • taxid: 1913 (view NCBI taxonomy browser)

  • Aspergillus nidulans FGSC A4
  • gram: n/a
  • synonyms: Emericella nidulans FGSC A4
  • taxid: 227321 (view NCBI taxonomy browser)

  • Aspergillus oryzae RIB40
  • gram: n/a
  • taxid: 510516 (view NCBI taxonomy browser)

  • Arthroderma benhamiae CBS 112371
  • taxid: 663331 (view NCBI taxonomy browser)

  • Trichophyton verrucosum HKI 0517
  • gram: n/a
  • taxid: 663202 (view NCBI taxonomy browser)

  • Streptomyces cattleya NRRL 8057 = DSM 46488
  • gram: positive
  • taxid: 1003195 (view NCBI taxonomy browser)

  • Links between organisms producing the ACV: Penicillium chrysogenum, Acremonium chrysogenum, Streptomyces clavuligerus, Lysobacter lactamgenus, Amycolatopsis lactamdurans, Aspergillus nidulans FGSC A4, Aspergillus oryzae RIB40, Arthroderma benhamiae CBS 112371, Trichophyton verrucosum HKI 0517, Streptomyces cattleya NRRL 8057 = DSM 46488
  • delta-L-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase: the order of peptide bond formation and timing of the epimerisation reaction
    Shiau CY, Baldwin JE, Byford MF, Sobey WJ, Schofield CJ, FEBS letters , 1995, Jan 16,358(1):97-100.
    DOI: 10.1016/0014-5793(94)01320-z
    pubMed: 7821439
  • The cephamycin biosynthetic genes pcbAB, encoding a large multidomain peptide synthetase, and pcbC of Nocardia lactamdurans are clustered together in an organization different from the same genes in Acremonium chrysogenum and Penicillium chrysogenum
    Coque JJR, Martin JF, Calzada JG, Liras P, Molecular microbiology , 1991, 5(5):1125-1133
    DOI: 10.1111/j.1365-2958.1991.tb01885.x
  • Gene clusters for beta-lactam antibiotics and control of their expression: why have clusters evolved, and from where did they originate?
    Coque JJR, Martin JF, Calzada JG, Liras P, International Microbiology , 2006, 9:9–19
    pubMed: 16636985


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