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alamethicin F50


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  • Norine ID: NOR00007
  • DOI: 10.26097/nor00007
  • Family: alamethicin
  • Synonym(s): alamethicin F50;
  • Activity: antibiotic
  • Class: peptaibol
  • Formula: C92H151N23O24
  • Monoisotopic mass: 1962.130232875 g/mol
  • Comment: The natural alpha-helical peptide antibiotic alamethicin forms voltage-gated ion channels in lipid membranes.
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
    • status: curated
    • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
    • view all entry history
  • Type: linear
  • Number of monomers: 20
  • Smiles: CC(C)CC(NC(=O)CNC(=O)C(C)(C)NC(=O)C(NC(=O)C(C)(C)NC(=O)C(CCC(N)=O)NC(=O)C(C)NC(=O)C(C)(C)NC(=O)C(C)NC(=O)C(C)(C)NC(=O)C1CCCN1C(=O)C(C)(C)NC(C)=O)C(C)C)C(=O)NC(C)(C)C(=O)N3CCCC3(C(=O)NC(C(C)C)C(=O)NC(C)(C)C(=O)NC(C)(C)C(=O)NC(CCC(N)=O)C(=O)NC(CCC(N)=O)C(=O)NC(CO)Cc2ccccc2)

  • Graph inference:



  • Monomeric composition :
    1
    Ac-Aib
    2
    Pro
    3
    Aib
    4
    Ala
    5
    Aib
    6
    Ala
    7
    Gln
    8
    Aib
    9
    Val
    10
    Aib
    11
    Gly
    12
    Leu
    13
    Aib
    14
    Pro
    15
    Val
    16
    Aib
    17
    Aib
    18
    Gln
    19
    Gln
    20
    Pheol
  • Graph representation: Ac-Aib,Pro,Aib,Ala,Aib,Ala,Gln,Aib,Val,Aib,Gly,Leu,Aib,Pro,Val,Aib,Aib,Gln,Gln,Pheol @1 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @8,10 @9,11 @10,12 @11,13 @12,14 @13,15 @14,16 @15,17 @16,18 @17,19 @18

  • Atomic structure:
    Chemical structure
  • Trichoderma viride
  • synonyms: Trichoderma lignorum
  • taxid: 5547 (view NCBI taxonomy browser)

  • Links between organisms producing the alamethicin F50: Trichoderma viride
  • Analysis of the lipophilic peptaibol alamethicin by nonaqueous capillary electrophoresis-electrospray ionization-mass spectrometry
    Psurek A, Neususs C, Pelzing M, Scriba GK, Electrophoresis , 2005, Nov,26(22):4368-78.
    DOI: 10.1002/elps.200500387
    pubMed: 16287177


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