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actinomycin D


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  • Norine ID: NOR00228
  • Family: actinomycin
  • Synonym(s): actinomycin D;
  • Activity: antibiotic, antitumor
  • Class: chromopeptide
  • Formula: C62H86N12O16
  • Monoisotopic mass: 1254.628474764 g/mol
  • Comment: Dactinomycin belongs to the group of medicines known as antineoplastics. It is used to treat some kinds of cancer of the bones and soft tissue, including muscles and tendons, Wilms tumor (a cancer of the kidney found primarily in children), tumors in the uterus or womb, and cancer of the testicles.
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
    • status: curated
    • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
    • view all entry history
  • Type: double cyclic
  • Number of monomers: 11
  • Smiles: CC(C)C6NC(=O)C(NC(=O)c3ccc(C)c4OC5=C(C)C(=O)C(N)=C(C(=O)NC1C(C)OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C2CCCN2(C(=O)C(NC1(=O))C(C)C))C5(=Nc34))C(C)OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C7CCCN7(C6(=O))

  • Graph inference:



  • Monomeric composition and PDB SEQRES:
    1
    Thr
    1
    THR
    2
    D-Val
    2
    DVA
    3
    Pro
    3
    PRO
    4
    NMe-Gly
    4
    SAR
    5
    NMe-Val
    5
    MVA
    6
    ChrAct
    6
    PXZ
    7
    Thr
    7
    THR
    8
    D-Val
    8
    DVA
    9
    Pro
    9
    PRO
    10
    NMe-Gly
    10
    SAR
    11
    NMe-Val
    11
    MVA
  • Graph representation: Thr,D-Val,Pro,NMe-Gly,NMe-Val,ChrAct,Thr,D-Val,Pro,NMe-Gly,NMe-Val @1,5,4 @0,2 @1,3 @2,4 @0,3 @0,6 @5,7,10 @6,8 @7,9 @8,10 @6,9

  • Atomic structure:
    Chemical structure
  • Streptomyces antibioticus
  • gram: positive
  • synonyms: Actinomyces antibioticus
  • taxid: 1890 (view NCBI taxonomy browser)

  • Streptomyces chrysomallus
  • gram: positive
  • synonyms: Streptomyces anulatus,Streptomyces fluorescens,Streptomyces citreofluorescens,Actinomyces fluorescens,Actinomyces citreofluorescens,Actinomyces annulatus,Actinomyces Streptothrix annulatus
  • taxid: 1892 (view NCBI taxonomy browser)

  • Streptomyces parvulus
  • gram: positive
  • taxid: 146923 (view NCBI taxonomy browser)

  • Links between organisms producing the actinomycin D: Streptomyces antibioticus, Streptomyces chrysomallus, Streptomyces parvulus
  • Molecular characterization of the genes of actinomycin synthetase I and of a 4-methyl-3-hydroxyanthranilic acid carrier protein involved in the assembly of the acylpeptide chain of actinomycin in Streptomyces
    Keller U, Pfennig F, Schauwecker F, The Journal of biological chemistry , 1999, Apr 30,274(18):12508-16.
    pubMed: 10212227


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