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lokisin


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  • Norine ID: NOR00342
  • Family: amphisin
  • Synonym(s): anikasin;
  • Activity: antibiotic, surfactant
  • Class: lipopeptide
  • Formula: C63H109N11O20
  • Monoisotopic mass: 1339.785034983 g/mol
  • Comment: Anikasin is a synonymous of lokisin. Only anikasin structure was experimentally elucidated.
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
    • status: curated
    • last modification date: 2019-02-20 by Sebastian Götze [University Koblenz-Landau Faculty 7: Natural and Environmental Sciences]
    • view all entry history
  • Type: partial cyclic
  • Number of monomers: 12
  • Smiles: CCCCCCC[C@H](CC(=O)N[C@H](CC(C)C)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H]1[C@H](OC(=O)[C@@H](NC(=O)[C@H](NC(=O)C(NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CC(C)C)CC(C)C)CO)CC(C)C)CO)CC(C)C)[C@H](C)CC)CC(=O)O)C)O

  • Graph inference:



  • Monomeric composition :
    1
    C10:0-OH(3)
    2
    D-Leu
    3
    D-Asp
    4
    D-aThr
    5
    D-Leu
    6
    D-Leu
    7
    D-Ser
    8
    Leu
    9
    D-Ser
    10
    Leu
    11
    Ile
    12
    Asp
  • Graph representation: C10:0-OH(3),D-Leu,D-Asp,D-aThr,D-Leu,D-Leu,D-Ser,Leu,D-Ser,Leu,Ile,Asp @1 @0,2 @1,3 @2,4,11 @3,5 @4,6 @5,7 @6,8 @7,9 @8,10 @9,11 @3,10

  • Atomic structure:
    Chemical structure
  • Pseudomonas sp. DSS41
  • gram: negative
  • synonyms:
  • taxid: (view NCBI taxonomy browser)

  • Pseudomonas fluorescens HKI0770
  • gram:

  • Links between organisms producing the lokisin: Pseudomonas sp. DSS41, Pseudomonas fluorescens HKI0770
  • Cyclic lipoundecapeptide lokisin from Pseudomonas sp. strain DSS41
    Nielsen TH, Christophersen C, Sorensen J, Sorensen D, Tetrahedron letters , 2002, 43 4421-4423.
  • Structure, Biosynthesis, and Biological Activity of the Cyclic Lipopeptide Anikasin
    Götze S, Klapper M, Stallforth P, Herbst-Irmer R, Görls H, Schneider KRA, Barnett R, Burks T, Neu U, ACS Chemical Biology , 2017, 12:2498-2502
    pubMed: 28846366


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