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dolastatin 15


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  • Norine ID: NOR00370
  • Family: dolastatin
  • Synonym(s): dolastatin 15;
  • Activity: antitumor
  • Class: peptide
  • Formula: C45H68N6O9
  • Monoisotopic mass: 836.5047778039999 g/mol
  • Comment: Potent inhibitor of the proliferation of murine and leukemia cell lines and also an inhibitor of hematopoietic progenitor cells. Also shown to inhibit microtubule assembly and to induce apoptosis and Bcl2 phosphorylation in many malignant cells types.
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
    • status: curated
    • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
    • view all entry history
  • Type: linear
  • Number of monomers: 7
  • Smiles: COC4=CC(=O)N(C(=O)C(OC(=O)C2CCCN2(C(=O)C1CCCN1(C(=O)C(C(C)C)N(C)C(=O)C(NC(=O)C(C(C)C)N(C)C)C(C)C)))C(C)C)C4(Cc3ccccc3)

  • Graph inference:



  • Monomeric composition :
    1
    Dov
    2
    Val
    3
    NMe-Val
    4
    Pro
    5
    Pro
    6
    Hiv
    7
    Dpy
  • Graph representation: Dov,Val,NMe-Val,Pro,Pro,Hiv,Dpy @1 @0,2 @1,3 @2,4 @3,5 @4,6 @5

  • Atomic structure:
    Chemical structure
  • Dolabella auricularia
  • taxid: 6511 (view NCBI taxonomy browser)

  • Links between organisms producing the dolastatin 15: Dolabella auricularia
  • Dolastatin 15 binds in the vinca domain of tubulin as demonstrated by Hummel-Dreyer chromatography
    Cruz-Monserrate Z, Mullaney JT, Harran PG, Pettit GR, Hamel E, European journal of biochemistry FEBS , 2003, Sep,270(18):3822-8.
    pubMed: 12950266


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