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didemnin B


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  • Norine ID: NOR00374
  • DOI: 10.26097/nor00374
  • Family: didemnin
  • Synonym(s): didemnin B;
  • Activity: antibiotic, antitumor, immunomodulating
  • Class: peptide
  • Formula: C57H89N7O15
  • Monoisotopic mass: 1111.641665213 g/mol
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
    • status: curated
    • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
    • view all entry history
  • Type: partial cyclic
  • Number of monomers: 9
  • Smiles: CCC(C)C3NC(=O)C(NC(=O)C(CC(C)C)N(C)C(=O)C1CCCN1(C(=O)C(C)O))C(C)OC(=O)C(Cc2ccc(cc2)OC)N(C)C(=O)C4CCCN4(C(=O)C(CC(C)C)NC(=O)C(C)C(=O)C(OC(=O)CC3(O))C(C)C)

  • Graph inference:



  • Monomeric composition :
    1
    Ist
    2
    Hip
    3
    Leu
    4
    Pro
    5
    NMe-OMe-Tyr
    6
    Thr
    7
    D-NMe-Leu
    8
    Pro
    9
    Lac
  • Graph representation: Ist,Hip,Leu,Pro,NMe-OMe-Tyr,Thr,D-NMe-Leu,Pro,Lac @1,5 @0,2 @1,3 @2,4 @3,5 @0,4,6 @5,7 @6,8 @7

  • Atomic structure:
    Chemical structure
  • Trididemnum solidum
  • gram:
  • synonyms:
  • taxid: 1079459 (view NCBI taxonomy browser)

  • Didemnum sp.
  • gram:
  • synonyms:
  • taxid: 107395 (view NCBI taxonomy browser)

  • Links between organisms producing the didemnin B: Trididemnum solidum, Didemnum sp.
  • Didemnin B induces apoptosis in proliferating but not resting peripheral blood mononuclear cells
    Baker MA, Grubb DR, Lawen A, Apoptosis : an international journal on programmed cell death , 2002, Oct,7(5):407-12.
    pubMed: 12207173
  • Natural products as probes of cell biology: 20 years of didemnin research
    Vera MD, Joullie MM, Medicinal research reviews , 2002, Mar,22(2):102-45.
    pubMed: 11857636


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