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hemiasterlin A


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  • Norine ID: NOR00457
  • DOI: 10.26097/nor00457
  • Family: hemiasterlin
  • Synonym(s): hemiasterlin A;
  • Activity: antitumor, toxin
  • Class: peptide
  • Formula: C29H44N4O4
  • Monoisotopic mass: 512.336255916 g/mol
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
    • status: putative
    • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
    • view all entry history
  • Type: linear
  • Number of monomers: 3
  • Smiles: CNC(C(=O)NC(C(=O)N(C)C(C=C(C)C(=O)O)C(C)C)C(C)(C)C)C(C)(C)c2c[nH]c1ccccc12

  • Graph inference:



  • Monomeric composition :
    1
    bbMe-NMe-Trp
    2
    t-Leu
    3
    NMe-hv-Val
  • Graph representation: bbMe-NMe-Trp,t-Leu,NMe-hv-Val @1 @0,2 @1

  • Atomic structure:
  • Chemical structure
    rBAN vizualisation:
  • Auletta sp.

  • Siphonochalina spp.

  • Cymbastela
  • taxid: 85785 (view NCBI taxonomy browser)

  • Links between organisms producing the hemiasterlin A: Auletta sp., Siphonochalina spp., Cymbastela
  • Cytotoxic peptides hemiasterlin, hemiasterlin A and hemiasterlin B induce mitotic arrest and abnormal spindle formation
    Andersen RJ, Anderson HJ, Coleman JE, Roberge M, Cancer chemotherapy and pharmacology , 1997, 39(3):223-6.
    DOI: 10.1007/s002800050564
    pubMed: 8996524
  • Cytotoxic and tubulin-interactive hemiasterlins from Auletta sp. and Siphonochalina spp. sponges
    Hamel E, Boyd MR, Gamble WR, Durso NA, Fuller RW, Westergaard CK, Johnson TR, Sackett DL, Cardellina JH, Bioorganic and medicinal chemistry , 1999, Aug,7(8):1611-5.
    DOI: 10.1016/s0968-0896(99)00089-9
    pubMed: 10482453


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