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moiramide B

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  • Norine ID: NOR00727
  • DOI: 10.26097/nor00727
  • Family: andrimid
  • Synonym(s): moiramide B;
  • Activity: antibiotic
  • Class: PK-NRP
  • Formula: C25H31N3O5
  • Monoisotopic mass: 453.226371117 g/mol
  • Comment: The pseudopeptide pyrrolidinedione natural products moiramide B and andrimid represent a new class of antibiotics that target bacterial fatty acid biosynthesis.
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
    • status: curated
    • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
    • view all entry history
  • Enterobacter
  • synonyms: Aerobacter,Cloaca
  • taxid: 547 (view NCBI taxonomy browser)

  • Vibrio
  • synonyms: Microspira,Pacinia
  • taxid: 662 (view NCBI taxonomy browser)

  • Pseudomonas
  • gram: negative
  • synonyms:
  • taxid: 286 (view NCBI taxonomy browser)

  • Links between organisms producing the moiramide B: Enterobacter, Vibrio, Pseudomonas
  • A biosynthetic gene cluster for the acetyl-CoA carboxylase inhibitor andrimid
    Jin M, Fischbach MA, Clardy J, Journal of the American Chemical Society , 2006, Aug 23,128(33):10660-1.
    DOI: 10.1021/ja063194c
    pubMed: 16910643
  • Pyrrolidinedione derivatives as antibacterial agents with a novel mode of action
    Pohlmann J, Lampe T, Shimada M, Nell PG, Pernerstorfer J, Svenstrup N, Brunner NA, Schiffer G, Freiberg C, Bioorganic and medicinal chemistry letters , 2005, 15,15(4):1189-92.
    DOI: 10.1016/j.bmcl.2004.12.002
    pubMed: 15686939

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