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ramoplanin A3


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  • Norine ID: NOR00845
  • DOI: 10.26097/nor00845
  • Family: ramoplanin
  • Synonym(s): ramoplanin A3;
  • Activity: antibiotic
  • Class: lipopeptide , glycopeptide
  • Formula: C120H156ClN21O40
  • Monoisotopic mass: 2566.050696687 g/mol
  • Comment: Ramoplanin factors A1, A2, and A3 were isolated in 12, 72, and 16% yields, respectively, from purification of the culture broth of Actinoplanes strain ATCC 33076.
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
    • status: curated
    • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
    • view all entry history
  • Type: partial cyclic
  • Number of monomers: 20
  • Smiles: CC(C)CCC=CC=CC(=O)NC(CC(N)=O)C(=O)NC%10C(=O)NC(c1ccc(O)cc1)C(=O)NC(CCCN)C(=O)NC(C(C)O)C(=O)NC(c2ccc(O)cc2)C(=O)NC(c3ccc(O)cc3)C(=O)NC(C(C)O)C(=O)NC(Cc4ccccc4)C(=O)NC(CCCN)C(=O)NC(c5ccc(cc5)OC7OC(CO)C(O)C(O)C7(OC6OC(CO)C(O)C(O)C6(O)))C(=O)NC(C(C)O)C(=O)NC(c8ccc(O)cc8)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(c9ccc(O)c(c9)Cl)C(=O)OC%10(C(N)=O)

  • Graph inference:



  • Monomeric composition :
    1
    iC10:2(2.t4)
    2
    Asn
    3
    OH-Asn
    4
    D-Hpg
    5
    D-Orn
    6
    D-aThr
    7
    Hpg
    8
    D-Hpg
    9
    aThr
    10
    Phe
    11
    D-Orn
    12
    Hpg
    13
    D-Man
    14
    D-Man
    15
    D-aThr
    16
    Hpg
    17
    Gly
    18
    Leu
    19
    D-Ala
    20
    Cl-Hpg
  • Graph representation: iC10:2(2.t4),Asn,OH-Asn,D-Hpg,D-Orn,D-aThr,Hpg,D-Hpg,aThr,Phe,D-Orn,Hpg,D-Man,D-Man,D-aThr,Hpg,Gly,Leu,D-Ala,Cl-Hpg @1 @0,2 @1,3,19 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @8,10 @9,11 @10,12,14 @11,13 @12 @11,15 @14,16 @15,17 @16,18 @17,19 @2,18

  • Atomic structure:
  • Chemical structure
    rBAN vizualisation:
  • Actinoplanes sp.
  • gram: positive
  • synonyms: Ampullariella sp.
  • taxid: 1871 (view NCBI taxonomy browser)

  • Links between organisms producing the ramoplanin A3: Actinoplanes sp.
  • Chemistry and biology of ramoplanin: a lipoglycodepsipeptide with potent antibiotic activity
    Walker S, Chen L, Hu Y, Rew Y, Shin D, Boger DL, Chemical reviews , 2005, Feb,105(2):449-76.
    DOI: 10.1021/cr030106n
    pubMed: 15700952
  • Chemistry and biology of the ramoplanin family of peptide antibiotics
    McCafferty DG, Cudic P, Frankel BA, Barkallah S, Kruger RG, Li W, Biopolymers , 2002, 66(4):261-84.
    DOI: 10.1002/bip.10296
    pubMed: 12491539


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