Norine

• Type:
• Smiles: COc1cc(C(=O)O[C@@H]([C@@]2(C)OC2)C(=O)N/C(=C\2/N3CC3[C@H]([C@@H]2OC(=O)C)O)/C(=O)N/C(=C/O)/C(=O)C)c2c(c1)c(C)ccc2
  
  
• Graph inference:


  Run Smiles2Monomers |   Run rBAN



• Atomic structure:

vizualisation:

• Streptomyces
• gram: positive
• taxid: 68187 (view NCBI taxonomy browser)

• Links between organisms producing the CARZINOPHILIN: Streptomyces

• Carzinophilin, a new tumor inhibitory substance produced by streptomyces. I.
  The Journal of antibiotics , 1954, 7(4):107-12
  pubMed: 13211477

• In vitro biosynthesis of the antitumor agent azinomycin B.
  Organic letters , 2006, 8(6):1065-8
  DOI: 10.1021/ol052987l
  pubMed: 16524269

• Characterization of the azinomycin B biosynthetic gene cluster revealing a different iterative type I polyketide synthase for naphthoate biosynthesis.
  Chemistry & biology , 2008, 15(7):693-705
  DOI: 10.1016/j.chembiol.2008.05.021
  pubMed: 18635006

• Azinomycins A and B, new antitumor antibiotics. I. Producing organism, fermentation, isolation, and characterization.
  The Journal of antibiotics , 1986, 39(11):1527-32
  DOI: 10.7164/antibiotics.39.1527
  pubMed: 3793621

• Mode of action and biosynthesis of the azabicycle-containing natural products azinomycin and ficellomycin.
  Natural product reports , 2011, 28(4):693-704
  DOI: 10.1039/c0np00049c
  pubMed: 21327255

• Azinomycins A and B, new antitumor antibiotics. III. Antitumor activity.
  The Journal of antibiotics , 1987, 40(1):60-5
  DOI: 10.7164/antibiotics.40.60
  pubMed: 3104267

• Studies on carzinophilin. I. The properties of carzinophilin A.
  The Journal of antibiotics , 1955, 8(6):187-8
  pubMed: 13319221

• Biosynthesis of 3-methoxy-5-methyl naphthoic acid and its incorporation into the antitumor antibiotic azinomycin B.
  Molecular bioSystems , 2010, 6(6):1071-81
  DOI: 10.1039/b926358f
  pubMed: 20485749

• Antitumor compounds from actinomycetes: from gene clusters to new derivatives by combinatorial biosynthesis.
  Natural product reports , 2009, 26(5):628-60
  DOI: 10.1039/b822528a
  pubMed: 19387499

  3757