Norine

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HOLOMYCIN


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  • Norine ID: NOR01921
  • Family: unknown
  • Synonym(s):
  • Activity: antimicrobial
  • Class:
  • Monoisotopic mass: 214.26474 g/mol
  • Source: StreptomeDB
  • Contributor (creation): Norine Bot [CRIStAL (UMR CNRS 9189), ex-LIFL, France]
  • Entry information:
  • Streptomyces griseus
  • gram: positive
  • synonyms: Actinomyces griseus
  • taxid: 1911 (view NCBI taxonomy browser)

  • Streptomyces clavuligerus
  • gram: positive
  • taxid: 443255 (view NCBI taxonomy browser)

  • Links between organisms producing the HOLOMYCIN: Streptomyces griseus, Streptomyces clavuligerus
  • Heterologous expression of natural product biosynthetic gene clusters in Streptomyces coelicolor: from genome mining to manipulation of biosynthetic pathways.
    Journal of industrial microbiology & biotechnology , 2014, 41(2):425-31
    DOI: 10.1007/s10295-013-1348-5
    pubMed: 24096958
  • A backup plan for self-protection: S-methylation of holomycin biosynthetic intermediates in Streptomyces clavuligerus.
    Chembiochem : a European journal of chemical biology , 2012, 13(17):2521-6
    DOI: 10.1002/cbic.201200536
    pubMed: 23097183
  • Identification of the gene cluster for the dithiolopyrrolone antibiotic holomycin in Streptomyces clavuligerus.
    Proceedings of the National Academy of Sciences of the United States of America , 2010, 107(46):19731-5
    DOI: 10.1073/pnas.1014140107
    pubMed: 21041678
  • Mutants of Streptomyces clavuligerus with disruptions in different genes for clavulanic acid biosynthesis produce large amounts of holomycin: possible cross-regulation of two unrelated secondary metabolic pathways.
    Journal of bacteriology , 2002, 184(23):6559-65
    DOI: 10.1128/jb.184.23.6559-6565.2002
    pubMed: 12426344


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