Norine

• Type:
• Smiles: CC(=O)Nc1c2sscc2[nH]c1=O
  
  
• Graph inference:


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• Atomic structure:

vizualisation:

• Streptomyces griseus
• gram: positive
• synonyms: Actinomyces griseus
• taxid: 1911 (view NCBI taxonomy browser)

• Streptomyces clavuligerus
• gram: positive
• taxid: 443255 (view NCBI taxonomy browser)

• Links between organisms producing the HOLOMYCIN: Streptomyces griseus, Streptomyces clavuligerus

• Heterologous expression of natural product biosynthetic gene clusters in Streptomyces coelicolor: from genome mining to manipulation of biosynthetic pathways.
  Journal of industrial microbiology & biotechnology , 2014, 41(2):425-31
  DOI: 10.1007/s10295-013-1348-5
  pubMed: 24096958

• Draft genome sequence of Streptomyces clavuligerus NRRL 3585, a producer of diverse secondary metabolites.
  Journal of bacteriology , 2010, 192(23):6317-8
  DOI: 10.1128/JB.00859-10
  pubMed: 20889745

• A backup plan for self-protection: S-methylation of holomycin biosynthetic intermediates in Streptomyces clavuligerus.
  Chembiochem : a European journal of chemical biology , 2012, 13(17):2521-6
  DOI: 10.1002/cbic.201200536
  pubMed: 23097183

• Induction of holomycin production and complex metabolic changes by the argR mutation in Streptomyces clavuligerus NP1.
  Applied and environmental microbiology , 2012, 78(9):3431-41
  DOI: 10.1128/AEM.07699-11
  pubMed: 22344669

• Identification of the gene cluster for the dithiolopyrrolone antibiotic holomycin in Streptomyces clavuligerus.
  Proceedings of the National Academy of Sciences of the United States of America , 2010, 107(46):19731-5
  DOI: 10.1073/pnas.1014140107
  pubMed: 21041678

• The fish pathogen Yersinia ruckeri produces holomycin and uses an RNA methyltransferase for self-resistance.
  The Journal of biological chemistry , 2013, 288(21):14688-97
  DOI: 10.1074/jbc.M112.448415
  pubMed: 23572522

• Dithiolopyrrolones: biosynthesis, synthesis, and activity of a unique class of disulfide-containing antibiotics.
  Natural product reports , 2014, 31(7):905-23
  DOI: 10.1039/c3np70106a
  pubMed: 24835149

• Role of the cmcH-ccaR intergenic region and ccaR overexpression in cephamycin C biosynthesis in Streptomyces clavuligerus.
  Applied microbiology and biotechnology , 2013, 97(13):5869-80
  DOI: 10.1007/s00253-013-4721-4
  pubMed: 23361841

• Exploiting adaptive laboratory evolution of Streptomyces clavuligerus for antibiotic discovery and overproduction.
  PloS one , 2012, 7(3):e33727
  DOI: 10.1371/journal.pone.0033727
  pubMed: 22470465

• Mutants of Streptomyces clavuligerus with disruptions in different genes for clavulanic acid biosynthesis produce large amounts of holomycin: possible cross-regulation of two unrelated secondary metabolic pathways.
  Journal of bacteriology , 2002, 184(23):6559-65
  DOI: 10.1128/jb.184.23.6559-6565.2002
  pubMed: 12426344

• Streptomyces clavuligerus HlmI is an intramolecular disulfide-forming dithiol oxidase in holomycin biosynthesis.
  Biochemistry , 2011, 50(21):4615-22
  DOI: 10.1021/bi200321c
  pubMed: 21504228

• Different proteins bind to the butyrolactone receptor protein ARE sequence located upstream of the regulatory ccaR gene of Streptomyces clavuligerus.
  Molecular microbiology , 2005, 56(3):824-35
  DOI: 10.1111/j.1365-2958.2005.04581.x
  pubMed: 15819635

• Transcriptional analysis and proteomics of the holomycin gene cluster in overproducer mutants of Streptomyces clavuligerus.
  Journal of biotechnology , 2013, 163(1):69-76
  DOI: 10.1016/j.jbiotec.2012.09.017
  pubMed: 23147422

• Holomycin, a dithiolopyrrolone compound produced by Streptomyces clavuligerus.
  Applied microbiology and biotechnology , 2014, 98(3):1023-30
  DOI: 10.1007/s00253-013-5410-z
  pubMed: 24323287

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