Norine

• Type:
• Smiles: C/C/1=C/C(O)C(=O)/C=C\C=C/c2nc(C(NC(=O)CC3(CC1)S(=O)SC(=O)C3(C)O)C)sc2
  
  
• Graph inference:


  Run Smiles2Monomers |   Run rBAN



• Atomic structure:

vizualisation:

• Streptomyces
• gram: positive
• taxid: 68187 (view NCBI taxonomy browser)

• Links between organisms producing the Leinamycin: Streptomyces

• Leinamycin, a new antitumor antibiotic from Streptomyces: producing organism, fermentation and isolation.
  The Journal of antibiotics , 1989, 42(12):1768-74
  DOI: 10.7164/antibiotics.42.1768
  pubMed: 2621160

• Identification and localization of the gene cluster encoding biosynthesis of the antitumor macrolactam leinamycin in Streptomyces atroolivaceus S-140.
  Journal of bacteriology , 2002, 184(24):7013-24
  DOI: 10.1128/jb.184.24.7013-7024.2002
  pubMed: 12446651

• Noncovalent DNA binding drives DNA alkylation by leinamycin: evidence that the Z,E-5-(thiazol-4-yl)-penta-2,4-dienone moiety of the natural product serves as an atypical DNA intercalator.
  Journal of the American Chemical Society , 2011, 133(44):17641-51
  DOI: 10.1021/ja2046149
  pubMed: 21954957

• Polyketide chain skipping mechanism in the biosynthesis of the hybrid nonribosomal peptide-polyketide antitumor antibiotic leinamycin in Streptomyces atroolivaceus S-140.
  Journal of natural products , 2006, 69(3):387-93
  DOI: 10.1021/np050467t
  pubMed: 16562841

• Utilization of the methoxymalonyl-acyl carrier protein biosynthesis locus for cloning the oxazolomycin biosynthetic gene cluster from Streptomyces albus JA3453.
  Journal of bacteriology , 2006, 188(11):4142-7
  DOI: 10.1128/JB.00173-06
  pubMed: 16707707

• Chain initiation in the leinamycin-producing hybrid nonribosomal peptide/polyketide synthetase from Streptomyces atroolivaceus S-140. Discrete, monofunctional adenylation enzyme and peptidyl carrier protein that directly load D-alanine.
  The Journal of biological chemistry , 2007, 282(28):20273-82
  DOI: 10.1074/jbc.M702814200
  pubMed: 17502372

• DC 107, a novel antitumor antibiotic produced by a Streptomyces sp.
  The Journal of antibiotics , 1989, 42(2):333-5
  DOI: 10.7164/antibiotics.42.333
  pubMed: 2925527

• Characterization of DNA damage induced by a natural product antitumor antibiotic leinamycin in human cancer cells.
  Chemical research in toxicology , 2010, 23(1):99-107
  DOI: 10.1021/tx900301r
  pubMed: 20017514

• Antitumor compounds from actinomycetes: from gene clusters to new derivatives by combinatorial biosynthesis.
  Natural product reports , 2009, 26(5):628-60
  DOI: 10.1039/b822528a
  pubMed: 19387499

• Leinamycin biosynthesis revealing unprecedented architectural complexity for a hybrid polyketide synthase and nonribosomal peptide synthetase.
  Chemistry & biology , 2004, 11(1):33-45
  DOI: 10.1016/j.chembiol.2003.12.014
  pubMed: 15112993

  995