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Triostin A


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  • Norine ID: NOR01924
  • Family: unknown
  • Synonym(s):
  • Activity: antimicrobial
  • Class:
  • Monoisotopic mass: 1087.23048 g/mol
  • Source: StreptomeDB
  • Contributor (creation): Norine Bot [CRIStAL (UMR CNRS 9189), ex-LIFL, France]
  • Entry information:
  • Type:
  • Smiles: CC1NC(=O)C(COC(=O)C(C(C)C)N(C)C(=O)C2CSSCC(N(C1=O)C)C(=O)N(C)C(C(C)C)C(=O)OCC(NC(=O)c1cnc3c(n1)cccc3)C(=O)NC(C(=O)N2C)C)NC(=O)c1cnc2c(n1)cccc2

  • Graph inference:



  • Atomic structure:
  • Chemical structure
    rBAN vizualisation:
  • Streptomyces echinatus
  • gram: positive
  • taxid: 67293 (view NCBI taxonomy browser)

  • Streptomyces
  • gram: positive
  • taxid: 68187 (view NCBI taxonomy browser)

  • Links between organisms producing the Triostin A: Streptomyces echinatus, Streptomyces
  • Studies on quinoxaline antibiotics. II. New antibiotics, triostins A, B and C.
    The Journal of antibiotics , 1961, 14:335-9
    pubMed: 14037700
  • Biosynthesis of quinoxaline antibiotics: purification and characterization of the quinoxaline-2-carboxylic acid activating enzyme from Streptomyces triostinicus.
    Biochemistry , 1990, 29(14):3522-7
    DOI: 10.1021/bi00466a015
    pubMed: 2354149
  • Functional cross-talk between fatty acid synthesis and nonribosomal peptide synthesis in quinoxaline antibiotic-producing streptomycetes.
    The Journal of biological chemistry , 2005, 280(6):4339-49
    DOI: 10.1074/jbc.M411026200
    pubMed: 15569690
  • Complete sequence of biosynthetic gene cluster responsible for producing triostin A and evaluation of quinomycin-type antibiotics from Streptomyces triostinicus.
    Biotechnology progress , 2008, 24(6):1226-31
    DOI: 10.1002/btpr.34
    pubMed: 19194935
  • Escherichia coli allows efficient modular incorporation of newly isolated quinomycin biosynthetic enzyme into echinomycin biosynthetic pathway for rational design and synthesis of potent antibiotic unnatural natural product.
    Journal of the American Chemical Society , 2009, 131(26):9347-53
    DOI: 10.1021/ja902261a
    pubMed: 19514719


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