Norine

• Type:
• Smiles: CC1NC(=O)C(COC(=O)C(C(C)C)N(C)C(=O)C2CSSCC(N(C1=O)C)C(=O)N(C)C(C(C)C)C(=O)OCC(NC(=O)c1cnc3c(n1)cccc3)C(=O)NC(C(=O)N2C)C)NC(=O)c1cnc2c(n1)cccc2
  
  
• Graph inference:


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• Atomic structure:

vizualisation:

• Streptomyces echinatus
• gram: positive
• taxid: 67293 (view NCBI taxonomy browser)

• Streptomyces
• gram: positive
• taxid: 68187 (view NCBI taxonomy browser)

• Links between organisms producing the Triostin A: Streptomyces echinatus, Streptomyces

• Studies on quinoxaline antibiotics. II. New antibiotics, triostins A, B and C.
  The Journal of antibiotics , 1961, 14:335-9
  pubMed: 14037700

• Structure and conformation of fourteen antibiotics of the quinoxaline group determined by 1H NMR.
  The Journal of antibiotics , 1982, 35(1):62-6
  DOI: 10.7164/antibiotics.35.62
  pubMed: 7068517

• The use of radiolabelled triostin antibiotics to measure low levels of binding to deoxyribonucleic acid.
  The Biochemical journal , 1983, 211(3):543-51
  DOI: 10.1042/bj2110543
  pubMed: 6309135

• Identification and stereochemical assignment of the beta-hydroxytryptophan intermediate in the echinomycin biosynthetic pathway.
  Organic letters , 2006, 8(21):4719-22
  DOI: 10.1021/ol061738+
  pubMed: 17020286

• Biosynthesis of quinoxaline antibiotics: purification and characterization of the quinoxaline-2-carboxylic acid activating enzyme from Streptomyces triostinicus.
  Biochemistry , 1990, 29(14):3522-7
  DOI: 10.1021/bi00466a015
  pubMed: 2354149

• Functional cross-talk between fatty acid synthesis and nonribosomal peptide synthesis in quinoxaline antibiotic-producing streptomycetes.
  The Journal of biological chemistry , 2005, 280(6):4339-49
  DOI: 10.1074/jbc.M411026200
  pubMed: 15569690

• Complete sequence of biosynthetic gene cluster responsible for producing triostin A and evaluation of quinomycin-type antibiotics from Streptomyces triostinicus.
  Biotechnology progress , 2008, 24(6):1226-31
  DOI: 10.1002/btpr.34
  pubMed: 19194935

• Escherichia coli allows efficient modular incorporation of newly isolated quinomycin biosynthetic enzyme into echinomycin biosynthetic pathway for rational design and synthesis of potent antibiotic unnatural natural product.
  Journal of the American Chemical Society , 2009, 131(26):9347-53
  DOI: 10.1021/ja902261a
  pubMed: 19514719

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