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Thaxtomine A


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  • Norine ID: NOR01927
  • Family: unknown
  • Synonym(s):
  • Activity:
  • Class:
  • Monoisotopic mass: 438.43328 g/mol
  • Source: StreptomeDB
  • Contributor (creation): Norine Bot [CRIStAL (UMR CNRS 9189), ex-LIFL, France]
  • Entry information:
  • Type:
  • Smiles: Oc1cccc(c1)C[C@]1(O)N(C)C(=O)[C@@H](N(C1=O)C)Cc1c[nH]c2c1c(ccc2)N(=O)=O

  • Graph inference:



  • Atomic structure:
  • Chemical structure
    rBAN vizualisation:
  • Streptomyces
  • gram: positive
  • taxid: 68187 (view NCBI taxonomy browser)

  • Streptomyces turgidiscabies
  • gram: positive
  • taxid: 698760 (view NCBI taxonomy browser)

  • Links between organisms producing the Thaxtomine A: Streptomyces, Streptomyces turgidiscabies
  • Thaxtomin A affects CESA-complex density, expression of cell wall genes, cell wall composition, and causes ectopic lignification in Arabidopsis thaliana seedlings.
    Journal of experimental botany , 2009, 60(3):955-65
    DOI: 10.1093/jxb/ern344
    pubMed: 19269997
  • Characterization of an insertion sequence element associated with genetically diverse plant pathogenic Streptomyces spp.
    Journal of bacteriology , 1999, 181(5):1562-8
    pubMed: 10049389
  • Cytochrome p450 complement (CYPome) of the avermectin-producer Streptomyces avermitilis and comparison to that of Streptomyces coelicolor A3(2).
    Biochemical and biophysical research communications , 2003, 307(3):610-9
    DOI: 10.1016/s0006-291x(03)01231-2
    pubMed: 12893267
  • Selection and characterization of microorganisms utilizing thaxtomin A, a phytotoxin produced by streptomyces scabies
    Applied and environmental microbiology , 1998, 64(11):4313-6
    pubMed: 9797282
  • Nitric oxide synthase inhibitors and nitric oxide donors modulate the biosynthesis of thaxtomin A, a nitrated phytotoxin produced by Streptomyces spp.
    Nitric oxide : biology and chemistry , 2005, 12(1):46-53
    DOI: 10.1016/j.niox.2004.11.004
    pubMed: 15631947
  • Enhanced resistance to the cellulose biosynthetic inhibitors, thaxtomin A and isoxaben in Arabidopsis thaliana mutants, also provides specific co-resistance to the auxin transport inhibitor, 1-NPA.
    BMC plant biology , 2013, 13:76
    DOI: 10.1186/1471-2229-13-76
    pubMed: 23638731
  • Plant cell growth and ion flux responses to the streptomycete phytotoxin thaxtomin A: calcium and hydrogen flux patterns revealed by the non-invasive MIFE technique.
    Plant & cell physiology , 2005, 46(4):638-48
    DOI: 10.1093/pcp/pci069
    pubMed: 15753107


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