Norine

• Type:
• Smiles: OC[C@@H]1O[C@@H](O[C@H]([C@@H](C(=O)N[C@@H]([C@H]([C@@H](C(=O)N[C@H](C(=O)NCCc2scc(n2)c2scc(n2)C(=O)NCCC[S+](C)C)[C@H](O)C)C)O)C)NC(=O)c2nc(nc(c2C)N)[C@H](CC(=O)N)NC[C@@H](C(=O)N)N)c2[nH]cnc2)[C@H]([C@H]([C@@H]1O)O)O[C@H]1O[C@H](CO)[C@H]([C@@H]([C@@H]1O)OC(=O)N)O
  
  
• Graph inference:


  Run Smiles2Monomers |   Run rBAN



• Atomic structure:

vizualisation:

• Links between organisms producing the bleomycin A2:

• A designer bleomycin with significantly improved DNA cleavage activity.
  Journal of the American Chemical Society , 2012, 134(32):13501-9
  DOI: 10.1021/ja3056535
  pubMed: 22831455

• BlmB and TlmB provide resistance to the bleomycin family of antitumor antibiotics by N-acetylating metal-free bleomycin, tallysomycin, phleomycin, and zorbamycin.
  Biochemistry , 2014, 53(44):6901-9
  DOI: 10.1021/bi501121e
  pubMed: 25299801

• Solution structure of Fe(II)-azide-bleomycin derived from NMR data: transition from Fe(II)-bleomycin to Fe(II)-azide-bleomycin as derived from NMR data and structural calculations.
  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry , 2012, 17(5):761-71
  DOI: 10.1007/s00775-012-0894-z
  pubMed: 22481631

  8772