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bleomycin A2


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  • Norine ID: NOR01946
  • Family: unknown
  • Synonym(s):
  • Activity: antimicrobial
  • Class:
  • Monoisotopic mass: 1415.55176 g/mol
  • Source: StreptomeDB
  • Contributor (creation): Norine Bot [CRIStAL (UMR CNRS 9189), ex-LIFL, France]
  • Entry information:
  • Type:
  • Smiles: OC[C@@H]1O[C@@H](O[C@H]([C@@H](C(=O)N[C@@H]([C@H]([C@@H](C(=O)N[C@H](C(=O)NCCc2scc(n2)c2scc(n2)C(=O)NCCC[S+](C)C)[C@H](O)C)C)O)C)NC(=O)c2nc(nc(c2C)N)[C@H](CC(=O)N)NC[C@@H](C(=O)N)N)c2[nH]cnc2)[C@H]([C@H]([C@@H]1O)O)O[C@H]1O[C@H](CO)[C@H]([C@@H]([C@@H]1O)OC(=O)N)O

  • Graph inference:



  • Atomic structure:
  • Chemical structure
    rBAN vizualisation:
  • Links between organisms producing the bleomycin A2:
  • BlmB and TlmB provide resistance to the bleomycin family of antitumor antibiotics by N-acetylating metal-free bleomycin, tallysomycin, phleomycin, and zorbamycin.
    Biochemistry , 2014, 53(44):6901-9
    DOI: 10.1021/bi501121e
    pubMed: 25299801
  • Solution structure of Fe(II)-azide-bleomycin derived from NMR data: transition from Fe(II)-bleomycin to Fe(II)-azide-bleomycin as derived from NMR data and structural calculations.
    Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry , 2012, 17(5):761-71
    DOI: 10.1007/s00775-012-0894-z
    pubMed: 22481631


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