Norine

• Type:
• Smiles: CO[C@@H]1C[C@@H](CC[C@H]1O)C[C@H]([C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@@H](CC[C@H]2C)C[C@H](OC)/C(=C/C=C/C=C\[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C1)C)/C)O)OC)C)C)/C)C
  
  
• Graph inference:


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• Atomic structure:

vizualisation:

• Streptomyces hygroscopicus
• gram: positive
• taxid: 132248 (view NCBI taxonomy browser)

• Links between organisms producing the rapamycin: Streptomyces hygroscopicus

• Bioactive compounds from marine actinomycetes.
  Indian journal of microbiology , 2008, 48(4):410-31
  DOI: 10.1007/s12088-008-0052-z
  pubMed: 23100742

• Comparative metabolic profiling-based improvement of rapamycin production by Streptomyces hygroscopicus.
  Applied microbiology and biotechnology , 2013, 97(12):5329-41
  DOI: 10.1007/s00253-013-4852-7
  pubMed: 23604534

• Waking up Streptomyces secondary metabolism by constitutive expression of activators or genetic disruption of repressors.
  Methods in enzymology , 2012, 517:343-66
  DOI: 10.1016/B978-0-12-404634-4.00017-6
  pubMed: 23084947

• Rapamycin and mTOR: a serendipitous discovery and implications for breast cancer.
  Clinical and translational medicine , 2012, 1(1):29
  DOI: 10.1186/2001-1326-1-29
  pubMed: 23369283

• Effects of dissolved oxygen level on rapamycin production by pellet-form of Streptomyces hygroscopicus.
  Journal of bioscience and bioengineering , 2013, 116(3):366-70
  DOI: 10.1016/j.jbiosc.2013.03.011
  pubMed: 23623896

• The expression of URGCP gene in prostate cancer cell lines: correlation with rapamycin.
  Molecular biology reports , 2012, 39(12):10173-7
  DOI: 10.1007/s11033-012-1891-6
  pubMed: 23007575

• Cascades and networks of regulatory genes that control antibiotic biosynthesis.
  Sub-cellular biochemistry , 2012, 64:115-38
  DOI: 10.1007/978-94-007-5055-5_6
  pubMed: 23080248

• Draft Genome Sequence of Streptomyces iranensis.
  Genome announcements , 2014, 2(4)
  DOI: 10.1128/genomeA.00616-14
  pubMed: 25035323

• An insight into the "-omics" based engineering of streptomycetes for secondary metabolite overproduction.
  BioMed research international , 2013, 2013:968518
  DOI: 10.1155/2013/968518
  pubMed: 24078931

• Long-term mTOR inhibitors administration evokes altered calcium homeostasis and platelet dysfunction in kidney transplant patients.
  Journal of cellular and molecular medicine , 2013, 17(5):636-47
  DOI: 10.1111/jcmm.12044
  pubMed: 23577651

• Production of rapamycin in Streptomyces hygroscopicus from glycerol-based media optimized by systemic methodology.
  Journal of microbiology and biotechnology , 2014, 24(10):1319-26
  pubMed: 25001557

• Evolutionary concepts in natural products discovery: what actinomycetes have taught us.
  Journal of industrial microbiology & biotechnology , 2014, 41(2):211-7
  DOI: 10.1007/s10295-013-1337-8
  pubMed: 24061567

• Recombinant strains for the enhanced production of bioengineered rapalogs.
  Metabolic engineering , 2013, 15:167-73
  DOI: 10.1016/j.ymben.2012.11.001
  pubMed: 23164580

• Draft Genome Sequence of Streptomyces rapamycinicus Strain NRRL 5491, the Producer of the Immunosuppressant Rapamycin.
  Genome announcements , 2013, 1(4)
  DOI: 10.1128/genomeA.00581-13
  pubMed: 23929477

• Studies on process optimization methods for rapamycin production using Streptomyces hygroscopicus ATCC 29253.
  Bioprocess and biosystems engineering , 2014, 37(5):829-40
  DOI: 10.1007/s00449-013-1051-y
  pubMed: 24048754

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