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actinomycin III


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  • Norine ID: NOR00231
  • DOI: 10.26097/nor00231
  • Family: actinomycin
  • Synonym(s): actinomycin III;
  • Activity: antibiotic
  • Class: chromopeptide
  • Formula: C60H88N12O18
  • Monoisotopic mass: 1264.6339540719998 g/mol
  • Comment: If sarcosine is added to the medium, the micro-organism produces, in addition to actinomycins D and I, actinomycin II and actinomycin III, characterized by the substitution by sarcosine of one or both the proline molecules present in actinomycin D.
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
    • status: curated
    • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
    • view all entry history
  • Type: double cyclic
  • Number of monomers: 11
  • Smiles: CC(C)C6NC(=O)C(NC(=O)C4=C(N)C(=O)C(C)=C3Oc5c(C)ccc(C(=O)NC1C(C)OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C2CCCN2(C(=O)C(NC1(=O))C(C)C))c5(N=C34))C(C)OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)CN(C)C6(=O)

  • Graph inference:



  • Monomeric composition :
    1
    D-Val
    2
    NMe-Gly
    3
    NMe-Gly
    4
    NMe-Val
    5
    Thr
    6
    ChrAct
    7
    Thr
    8
    D-Val
    9
    Pro
    10
    NMe-Gly
    11
    NMe-Val
  • Graph representation: D-Val,NMe-Gly,NMe-Gly,NMe-Val,Thr,ChrAct,Thr,D-Val,Pro,NMe-Gly,NMe-Val @1,4 @0,2 @1,3 @2,4 @0,3,5 @4,6 @5,7,10 @6,8 @7,9 @8,10 @6,9

  • Atomic structure:
  • Chemical structure
    rBAN vizualisation:
  • Streptomyces antibioticus
  • gram: positive
  • synonyms: Actinomyces antibioticus
  • taxid: 1890 (view NCBI taxonomy browser)

  • Streptomyces chrysomallus
  • gram: positive
  • synonyms: Streptomyces anulatus,Streptomyces fluorescens,Streptomyces citreofluorescens,Actinomyces fluorescens,Actinomyces citreofluorescens,Actinomyces annulatus,Actinomyces Streptothrix annulatus
  • taxid: 1892 (view NCBI taxonomy browser)

  • Streptomyces sp.
  • gram: positive
  • synonyms:
  • taxid: 1931 (view NCBI taxonomy browser)

  • Links between organisms producing the actinomycin III: Streptomyces antibioticus, Streptomyces chrysomallus, Streptomyces sp.


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