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halipeptin D


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  • Norine ID: NOR00455
  • DOI: 10.26097/nor00455
  • Family: halipeptin
  • Synonym(s): halipeptin D;
  • Activity: antiinflammatory
  • Class: peptide
  • Formula: C31H54N4O6S
  • Monoisotopic mass: 610.37640618 g/mol
  • Comment: Halipeptin is a putative NRPS product (no synthetase genes identified).
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
  • Type: cyclic
  • Number of monomers: 5
  • Smiles: CCC[C@@H](CC[C@@H](C)[C@H]1C(C(=O)N[C@H](C2=N[C@@](CS2)(C(=O)N([C@H](C(=O)N[C@H](C(=O)O1)C)[C@@H](C)CC)C)C)C)(C)C)OC

  • Graph inference:



  • Monomeric composition :
    1
    C10:0-Me(2.2.4)-OH(3)-OMe(7)
    2
    Ala
    3
    aMe-Cys
    4
    NMe-Ile
    5
    Ala
  • Graph representation: C10:0-Me(2.2.4)-OH(3)-OMe(7),Ala,aMe-Cys,NMe-Ile,Ala @1,4 @0,2 @1,3 @2,4 @0,3

  • Atomic structure:
  • Chemical structure
    rBAN vizualisation:
  • Leiosella cf. arenifibrosa

  • Links between organisms producing the halipeptin D: Leiosella cf. arenifibrosa
  • Total synthesis of halipeptins: isolation of halipeptin D and synthesis of oxazoline halipeptin analogues
    Nicolaou KC, Schlawe D, Kim DW, Longbottom DA, de Noronha RG, Lizos DE, Manam RR, Faulkner DJ, Chemistry , 2005, Oct 21,11(21):6197-211.
    DOI: 10.1002/chem.200500624
    pubMed: 16075448


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