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polytheonamide B

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  • Norine ID: NOR00669
  • DOI: 10.26097/nor00669
  • Family: polytheonamide
  • Synonym(s): polytheonamide B;
  • Activity: antitumor
  • Class: peptide
  • Formula: C219H376N60O72S
  • Monoisotopic mass: 5030.7325758160005 g/mol
  • Comment: Polytheonamides are by far the largest nonribosomal peptides. Two variants (A and C) exist and are isomeric.
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
    • status: curated
    • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
    • view all entry history
  • Theonella swinhoei
  • taxid: 37505 (view NCBI taxonomy browser)

  • Links between organisms producing the polytheonamide B: Theonella swinhoei
  • Polytheonamides A and B, highly cytotoxic, linear polypeptides with unprecedented structural features, from the marine sponge, Theonella swinhoei
    Matsunaga S, Fusetani N, Hamada T, Yano G, Journal of the American Chemical Society , 2005, Jan 12,127(1):110-8.
    DOI: 10.1021/ja045749e
    pubMed: 15631460

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