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bergofungin A


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  • Norine ID: NOR00964
  • DOI: 10.26097/nor00964
  • Family: bergofungin
  • Synonym(s):
  • Activity: antibiotic
  • Class: peptaibol
  • Formula: C73H120N16O19
  • Monoisotopic mass: 1524.891565738 g/mol
  • Comment:
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
    • status: curated
    • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
    • view all entry history
  • Type: linear
  • Number of monomers: 15
  • Smiles: CC[C@@](C)(C(=O)N1C[C@@H](C[C@H]1C(=O)NC(C)(C)C(=O)N[C@@H](CC2=CC=CC=C2)CO)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@@H]3C[C@H](CN3C(=O)C(C)(C)NC(=O)C(C)(C)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)C(C)(C)NC(=O)C(C)(C)NC(=O)C(C)(C)NC(=O)[C@H](C(C)C)NC(=O)C)O

  • Graph inference:



  • Monomeric composition :
    1
    Ac-Val
    2
    Aib
    3
    Aib
    4
    Aib
    5
    Val
    6
    Gly
    7
    Leu
    8
    Aib
    9
    Aib
    10
    4OH-Pro
    11
    Gln
    12
    Ival
    13
    4OH-Pro
    14
    Aib
    15
    Pheol
  • Graph representation: Ac-Val,Aib,Aib,Aib,Val,Gly,Leu,Aib,Aib,4OH-Pro,Gln,Ival,4OH-Pro,Aib,Pheol @1 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @8,10 @9,11 @10,12 @11,13 @12,14 @13

  • Atomic structure:
    Chemical structure
  • Emericellopsis donezkii
  • gram:
  • synonyms:
  • taxid: 281368 (view NCBI taxonomy browser)

  • Links between organisms producing the bergofungin A: Emericellopsis donezkii
  • Isolation and structure of bergofungin, a new antifungal peptaibol from Emericellopsis donezkii HKI 0059
    Ritzau M, Heinze S, Berg A, Schlegel B, Grafe U, Ihn W, Fleck WF, The Journal of antibiotics , 1996, Aug,49(8):817-20.
    DOI: 10.7164/antibiotics.49.817
    pubMed: 8823517
  • A natural, single-residue substitution yields a less active peptaibiotic: the structure of bergofungin A at atomic resolution.
    R. Gessmann, D. Axford, H. Brückner, A. Berg and K. Petratos, Acta Crystallographica. Section F, Structural Biology Communications , 2017, 73:95-100
    DOI: 10.1107/S2053230X17001236
    pubMed: 28177320


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