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harzianin HC III


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  • Norine ID: NOR00989
  • Family: harzianin
  • Synonym(s): harzianin HC III;
  • Activity: antibiotic
  • Class: peptaibol
  • Formula: C68H117N15O17
  • Monoisotopic mass: 1415.875187393 g/mol
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
    • status: curated
    • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
    • view all entry history
  • Type: linear
  • Number of monomers: 14
  • Smiles: CC[C@](C)(C(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)CO)NC(=O)[C@@H]2CCCN2C(=O)C(C)(C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H]3CCCN3C(=O)C(C)(C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)N)NC(=O)C(C)(C)NC(=O)C

  • Graph inference:



  • Monomeric composition :
    1
    Ac-Aib
    2
    Asn
    3
    Leu
    4
    Aib
    5
    Pro
    6
    Ser
    7
    Val
    8
    Aib
    9
    Pro
    10
    Ival
    11
    Leu
    12
    Aib
    13
    Pro
    14
    Leuol
  • Graph representation: Ac-Aib,Asn,Leu,Aib,Pro,Ser,Val,Aib,Pro,Ival,Leu,Aib,Pro,Leuol @1 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @8,10 @9,11 @10,12 @11,13 @12

  • Atomic structure:
    Chemical structure
  • Trichoderma harzianum
  • synonyms: Hypocrea lixii
  • taxid: 5544 (view NCBI taxonomy browser)

  • Links between organisms producing the harzianin HC III: Trichoderma harzianum
  • Interaction of the 14-residue peptaibols, harzianins HC, with lipid bilayers: permeability modifications and conductance properties
    Rebuffat S, Goulard C, Bodo B, Lucaciu M, Duclohier H, Molle G, Biochimica et biophysica acta , 1997, Jan 14,1323(1):85-96.
    pubMed: 9030215
  • ANTIBIOTIC PEPTIDES FROM TRICHODERMA HARZIANUM: HARZIANINS HC, PROLINE-RICH 14-RESIDUE PEPTAIBOLS
    Rebuffat S, Goulard C, Bodo B, Journal of the Chemical Society. Perkin transactions , 1995, no14,??pp.??1849-1855


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