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triostin A


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  • Norine ID: NOR01129
  • Family: triostin
  • Synonym(s): triostin A;
  • Activity: antibiotic, antitumor
  • Class: peptide
  • Formula: C50H62N12O12S2
  • Monoisotopic mass: 1086.405156908 g/mol
  • Comment: Quinomycins contain a thioacetal cross bridge. In the tiostin analogues, a disulfide bond replaces the thioacetal cross-link.
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
    • status: curated
    • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
    • view all entry history
  • Type: partial cyclic
  • Number of monomers: 10
  • Smiles: CC(C)C3C(=O)OCC(NC(=O)c1cnc2ccccc2(n1))C(=O)NC(C)C(=O)N(C)C4CSSCC(C(=O)N3(C))N(C)C(=O)C(C)NC(=O)C(COC(=O)C(C(C)C)N(C)C4(=O))NC(=O)c5cnc6ccccc6(n5)

  • Graph inference:



  • Monomeric composition and PDB SEQRES:
    1 2
    COOH-Qui D-Ser
    0
    QDS
    3
    Ala
    1
    ALA
    4
    NMe-Cys
    2
    NCY
    5
    NMe-Val
    3
    MVA
    6 7
    D-Ser COOH-Qui
    4
    QDS
    8
    Ala
    5
    ALA
    9
    NMe-Cys
    6
    NCY
    10
    NMe-Val
    7
    MVA
  • Graph representation: COOH-Qui,D-Ser,Ala,NMe-Cys,NMe-Val,D-Ser,COOH-Qui,Ala,NMe-Cys,NMe-Val @1 @0,2,9 @1,3 @2,4,8 @3,5 @4,6,7 @5 @5,8 @3,7,9 @1,8

  • Atomic structure:
    Chemical structure
  • Streptomyces sp.
  • gram: positive
  • taxid: 1931 (view NCBI taxonomy browser)

  • Links between organisms producing the triostin A: Streptomyces sp.
  • Structure confirmation of triostin a by 1H and 13C magnetic resonance
    Shoji J, Otsuka H, Kawano K, Kyogoku Y, The Journal of antibiotics , 1976, Jan,29(1):107-10.
    pubMed: 931789


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