Norine

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DAPTOMYCIN


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  • Norine ID: NOR01843
  • Family: unknown
  • Synonym(s):
  • Activity:
  • Class:
  • Monoisotopic mass: 1620.67064 g/mol
  • Source: StreptomeDB
  • Contributor (creation):
  • Entry information:
  • Type: partial cyclic
  • Number of monomers: 14
  • Smiles: CCCCCCCCCC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(N)=O)C(=O)NC(CC(=O)O)C(=O)NC4C(C)OC(=O)C(CC(=O)c3ccccc3(N))NC(=O)C(NC(=O)C(CO)NC(=O)CNC(=O)C(CC(=O)O)NC(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(CCCN)NC(=O)CNC4(=O))C(C)CC(=O)O

  • Graph inference:



  • Monomeric composition :
    1
    Thr
    2
    C10:0
    3
    Asp
    4
    Gly
    5
    Gly
    6
    Asn
    7
    Asp
    8
    Trp
    9
    Orn
    10
    Kyn
    11
    Ser
    12
    3Me-Glu
    13
    Asp
    14
    Ala
  • Graph representation: Thr,C10:0,Asp,Gly,Gly,Asn,Asp,Trp,Orn,Kyn,Ser,3Me-Glu,Asp,Ala @3,9,12 @7 @4,13 @0,8 @2,10 @7,12 @8,13 @1,5 @3,6 @0,11 @4,11 @9,10 @0,5 @2,6

  • Atomic structure:
  • Chemical structure
    rBAN vizualisation:
  • Streptomyces roseosporus
  • gram: positive
  • synonyms: Streptomyces filamentosus,Streptomyces venezuelae subsp. roseospori,Streptomyces roseisporus
  • taxid: 67294 (view NCBI taxonomy browser)

  • Links between organisms producing the DAPTOMYCIN: Streptomyces roseosporus
  • Imaging mass spectrometry and genome mining via short sequence tagging identified the anti-infective agent arylomycin in Streptomyces roseosporus.
    Journal of the American Chemical Society , 2011, 133(45):18010-3
    DOI: 10.1021/ja2040877
    pubMed: 21999343
  • Stereospecific enzymatic transformation of alpha-ketoglutarate to (2S,3R)-3-methyl glutamate during acidic lipopeptide biosynthesis.
    Journal of the American Chemical Society , 2007, 129(39):12011-8
    DOI: 10.1021/ja074427i
    pubMed: 17784761
  • Strain improvement of Streptomyces roseosporus for daptomycin production by rational screening of He-Ne laser and NTG induced mutants and kinetic modeling.
    Applied biochemistry and biotechnology , 2011, 163(6):729-43
    DOI: 10.1007/s12010-010-9078-x
    pubMed: 20886375
  • Fatty acyl-AMP ligase involvement in the production of alkylresorcylic acid by a Myxococcus xanthus type III polyketide synthase.
    Chembiochem : a European journal of chemical biology , 2011, 12(14):2166-76
    DOI: 10.1002/cbic.201100344
    pubMed: 21815236
  • The lipopeptide antibiotic A54145 biosynthetic gene cluster from Streptomyces fradiae
    Baltz RH, Miao V, Brost R, Chapple J, She K, Gal MF, Journal of industrial microbiology and biotechnology , 2006, Feb,33(2):129-40. Epub 2005 Oct 6.
    DOI: 10.1007/s10295-005-0028-5
    pubMed: 16208464
  • Daptomycin biosynthesis in Streptomyces roseosporus: cloning and analysis of the gene cluster and revision of peptide stereochemistry
    Miao V, Coeffet-Legal MF, Brian P, Brost R, Penn J, Whiting A, Martin S, Ford R, Parr I, Bouchard M, Silva CJ, Wrigley SK, Baltz RH, Microbiology , 2005, May,151(Pt 5):1507-23.
    DOI: 10.1099/mic.0.27757-0
    pubMed: 15870461


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