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daptomycin


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  • Norine ID: NOR00001
  • DOI: 10.26097/nor00001
  • Family: daptomycin
  • Synonym(s): daptomycin;
  • Activity: antibiotic
  • Class: lipopeptide
  • Formula: C72H101N17O26
  • Monoisotopic mass: 1619.710366489 g/mol
  • Comment: A21978C is a complex of lipopeptides which differ on their fatty acid moiety. It is used to treat complicated skin infections.
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
    • status: curated
    • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
    • view all entry history
  • Type: partial cyclic
  • Number of monomers: 14
  • Smiles: CCCCCCCCCC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(N)=O)C(=O)NC(CC(=O)O)C(=O)NC4C(C)OC(=O)C(CC(=O)c3ccccc3(N))NC(=O)C(NC(=O)C(CO)NC(=O)CNC(=O)C(CC(=O)O)NC(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(CCCN)NC(=O)CNC4(=O))C(C)CC(=O)O

  • Graph inference:



  • Monomeric composition :
    1
    C10:0
    2
    Trp
    3
    D-Asn
    4
    Asp
    5
    Thr
    6
    Gly
    7
    Orn
    8
    Asp
    9
    D-Ala
    10
    Asp
    11
    Gly
    12
    D-Ser
    13
    3Me-Glu
    14
    Kyn
  • Graph representation: C10:0,Trp,D-Asn,Asp,Thr,Gly,Orn,Asp,D-Ala,Asp,Gly,D-Ser,3Me-Glu,Kyn @1 @0,2 @1,3 @2,4 @3,5,13 @4,6 @5,7 @6,8 @7,9 @8,10 @9,11 @10,12 @11,13 @4,12

  • Atomic structure:
    Chemical structure
  • Streptomyces roseosporus
  • gram: positive
  • synonyms: Streptomyces filamentosus,Streptomyces venezuelae subsp. roseospori,Streptomyces roseisporus
  • taxid: 67294 (view NCBI taxonomy browser)

  • Links between organisms producing the daptomycin: Streptomyces roseosporus
  • A21978C, a complex of new acidic peptide antibiotics: isolation, chemistry, and mass spectral structure elucidation
    Debono M, Barnhart M, Carrell CB, Hoffmann JA, Occolowitz JL, Abbott BJ, Fukuda DS, Hamill RL, Biemann K, Herlihy WC, The Journal of antibiotics , 1987, Jun,40(6):761-77.
    DOI: 10.7164/antibiotics.40.761
    pubMed: 3610833
  • Daptomycin biosynthesis in Streptomyces roseosporus: cloning and analysis of the gene cluster and revision of peptide stereochemistry
    Miao V, Coeffet-Legal MF, Brian P, Brost R, Penn J, Whiting A, Martin S, Ford R, Parr I, Bouchard M, Silva CJ, Wrigley SK, Baltz RH, Microbiology , 2005, May,151(Pt 5):1507-23.
    DOI: 10.1099/mic.0.27757-0
    pubMed: 15870461


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