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cyclosporin A


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  • Norine ID: NOR00033
  • Family: cyclosporin
  • Synonym(s): cyclosporin A;
  • Activity: immunomodulating, antibiotic
  • Class: peptide
  • Formula: C62H111N11O12
  • Monoisotopic mass: 1201.841368071 g/mol
  • Comment: Cyclosporin is the primary tool used to prevent rejection following solid organ and bone marrow transplantation. It was first isolated as anti-fungal compound.
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
    • status: curated
    • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
    • view all entry history
  • Tolypocladium inflatum
  • gram:
  • synonyms: Tolypocladium niveum,Beauveria nivea
  • taxid: 29910 (view NCBI taxonomy browser)

  • Links between organisms producing the cyclosporin A: Tolypocladium inflatum
  • Multifunctional Peptide Synthetases
    von Dohren H, Keller U, Vater J, Zocher R, Chemical reviews , 1997, Nov 10,97(7):2675-2706.
    pubMed: 11851477
  • Cyclosporin synthetase. The most complex peptide synthesizing multienzyme polypeptide so far described
    Zocher R, Lawen A, The Journal of biological chemistry , 1990, Jul 5,265(19):11355-60.
    pubMed: 2358465


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