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actinomycin VII


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  • Norine ID: NOR00234
  • DOI: 10.26097/nor00234
  • Family: actinomycin
  • Synonym(s): actinomycin VII;
  • Activity: antibiotic, antitumor
  • Class: chromopeptide
  • Formula: C64H90N12O16
  • Monoisotopic mass: 1282.6597748919999 g/mol
  • Comment: The principal effect of D-alloisoleucine and, especially, D-isoleucine, is to bring about synthesis of two new actinomycins which contain N-methylisoleucine.
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
    • status: curated
    • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
    • view all entry history
  • Type: double cyclic
  • Number of monomers: 11
  • Smiles: CCC(C)C6NC(=O)C(NC(=O)c3ccc(C)c4OC5=C(C)C(=O)C(N)=C(C(=O)NC1C(C)OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C2CCCN2(C(=O)C(NC1(=O))C(C)CC))C5(=Nc34))C(C)OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C7CCCN7(C6(=O))

  • Graph inference:



  • Monomeric composition :
    1
    D-aIle
    2
    Pro
    3
    NMe-Gly
    4
    NMe-Val
    5
    Thr
    6
    ChrAct
    7
    Thr
    8
    D-aIle
    9
    Pro
    10
    NMe-Gly
    11
    NMe-Val
  • Graph representation: D-aIle,Pro,NMe-Gly,NMe-Val,Thr,ChrAct,Thr,D-aIle,Pro,NMe-Gly,NMe-Val @1,4 @0,2 @1,3 @2,4 @0,3,5 @4,6 @5,7,10 @6,8 @7,9 @8,10 @6,9

  • Atomic structure:
  • Chemical structure
    rBAN vizualisation:
  • Streptomyces chrysomallus
  • gram: positive
  • synonyms: Streptomyces anulatus,Streptomyces fluorescens,Streptomyces citreofluorescens,Actinomyces fluorescens,Actinomyces citreofluorescens,Actinomyces annulatus,Actinomyces Streptothrix annulatus
  • taxid: 1892 (view NCBI taxonomy browser)

  • Streptomyces sp.
  • gram: positive
  • synonyms:
  • taxid: 1931 (view NCBI taxonomy browser)

  • Links between organisms producing the actinomycin VII: Streptomyces chrysomallus, Streptomyces sp.
  • Role of valine and isoleucine as regulators of actinomycin peptide formation by Streptomyces chrysomallus
    Katz E, WALDRON CR, MELONI ML, Journal of bacteriology , 1961, Oct,82:600-8.
    pubMed: 14454374


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