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gramicidin S


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  • Norine ID: NOR00249
  • Family: gramicidin
  • Synonym(s): gramicidin S;
  • Activity: antibiotic
  • Class: peptide
  • Formula: C60H92N12O10
  • Monoisotopic mass: 1140.705937224 g/mol
  • Comment: It is a decapeptide which forms a cylic beta-sheet conformation , consisting of two antiparallel beta-strands connected by type II-turns.
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
    • status: curated
    • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
    • view all entry history
  • Type: cyclic
  • Number of monomers: 10
  • Smiles: CC(C)CC3NC(=O)C(CCCN)NC(=O)C(NC(=O)C5CCCN5(C(=O)C(Cc1ccccc1)NC(=O)C(CC(C)C)NC(=O)C(CCCN)NC(=O)C(NC(=O)C4CCCN4(C(=O)C(Cc2ccccc2)NC3(=O)))C(C)C))C(C)C

  • Graph inference:



  • Monomeric composition :
    1
    Val
    2
    Orn
    3
    Leu
    4
    D-Phe
    5
    Pro
    6
    Val
    7
    Orn
    8
    Leu
    9
    D-Phe
    10
    Pro
  • Graph representation: Val,Orn,Leu,D-Phe,Pro,Val,Orn,Leu,D-Phe,Pro @1,9 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @0,8

  • Atomic structure:
    Chemical structure
  • Bacillus brevis
  • gram: positive
  • synonyms: Brevibacillus brevis
  • taxid: 1393 (view NCBI taxonomy browser)

  • Links between organisms producing the gramicidin S: Bacillus brevis
  • Substrate recognition and selection by the initiation module PheATE of gramicidin S synthetase
    Luo L, Burkart MD, Stachelhaus T, Walsh CT, Journal of the American Chemical Society , 2001, Nov 14,123(45):11208-18.
    pubMed: 11697963


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