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tyrocidine C


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  • Norine ID: NOR00300
  • Family: tyrocidine
  • Synonym(s): tyrocidine C;
  • Activity: antibiotic
  • Class: peptide
  • Formula: C70H89N15O13
  • Monoisotopic mass: 1347.6764280090001 g/mol
  • Comment: Tyrocidine kills bacteria by interacting with their cytoplasmic membrane and causing leakage of their intracellular content. It also affects intracellular membranes such as those of mitochondria.
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
    • status: curated
    • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
    • view all entry history
  • Type: cyclic
  • Number of monomers: 10
  • Smiles: CC(C)CC7NC(=O)C(CCCN)NC(=O)C(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(Cc4c[nH]c5ccccc45)NC(=O)C8CCCN8(C(=O)C(Cc6ccccc6)NC7(=O)))C(C)C

  • Graph inference:



  • Monomeric composition :
    1
    D-Phe
    2
    Pro
    3
    Trp
    4
    D-Trp
    5
    Asn
    6
    Gln
    7
    Tyr
    8
    Val
    9
    Orn
    10
    Leu
  • Graph representation: D-Phe,Pro,Trp,D-Trp,Asn,Gln,Tyr,Val,Orn,Leu @1,9 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @0,8

  • Atomic structure:
    Chemical structure
  • Bacillus brevis
  • gram: positive
  • synonyms: Brevibacillus brevis
  • taxid: 1393 (view NCBI taxonomy browser)

  • Links between organisms producing the tyrocidine C: Bacillus brevis
  • The tyrocidine biosynthesis operon of Bacillus brevis: complete nucleotide sequence and biochemical characterization of functional internal adenylation domains
    Mootz HD, Marahiel MA, Journal of bacteriology , 1997, Nov,179(21):6843-50.
    pubMed: 9352938


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