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beauverolide I


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  • Norine ID: NOR00326
  • DOI: 10.26097/nor00326
  • Family: beauverolide
  • Synonym(s):
  • Activity: antiatherogenic
  • Class: lipopeptide
  • Formula: C27H41N3O5
  • Monoisotopic mass: 487.304621437 g/mol
  • Comment: Recent studies have indicated that beauverolides could potentially serve as new drugs for the treatment of atherosclerosis.
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
    • status: curated
    • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
    • view all entry history
  • Type: cyclic
  • Number of monomers: 4
  • Smiles: CCCCC(C)C1CC(=O)NC(CC2=CC=CC=C2)C(=O)NC(C)C(=O)NC(CC(C)C)C(=O)O1

  • Graph inference:



  • Monomeric composition :
    1
    C8:0-Me(4)-OH(3)
    2
    Phe
    3
    Ala
    4
    D-Leu
  • Graph representation: C8:0-Me(4)-OH(3),Phe,Ala,D-Leu @1,3 @0,2 @1,3 @0,2

  • Atomic structure:
  • Chemical structure
    rBAN vizualisation:
  • Beauveria vermiconia
  • gram: n/a
  • synonyms:
  • taxid: 37996 (view NCBI taxonomy browser)

  • Beauveria bassiana
  • gram: n/a
  • synonyms: Cordyceps bassiana,Tritirachium shiotae
  • taxid: 176275 (view NCBI taxonomy browser)

  • Paecilomyces fumosoroseus
  • gram: n/a
  • synonyms:
  • taxid: 114497 (view NCBI taxonomy browser)

  • Links between organisms producing the beauverolide I: Beauveria vermiconia, Beauveria bassiana, Paecilomyces fumosoroseus
  • Sequencing of new beauverolides by high-performance liquid chromatography and mass spectrometry
    Kuzma M, Jegorov A, Kacer P, Havlicek V, Journal of mass spectrometry , 2001, Oct,36(10):1108-15.
    DOI: 10.1002/jms.213
    pubMed: 11747104
  • Extraribosomal cyclic tetradepsipeptides beauverolides: profiling and modeling the fragmentation pathways
    Kuzma M, Jegorov A, Havlicek V, Paizs B, Zabka M, Landa Z, Sulc M, Barrow MP, Journal of mass spectrometry , 2004, Aug,39(8):949-60.
    DOI: 10.1002/jms.674
    pubMed: 15329847
  • Antiatherogenic activity of fungal beauveriolides, inhibitors of lipid droplet accumulation in macrophages
    Namatame I, Tomoda H, Ishibashi S, Omura S, Proceedings of the National Academy of Sciences of the United States of America , 2004, 20,101(3):737-42.
    DOI: 10.1073/pnas.0307757100
    pubMed: 14718664


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