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jaspamide


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  • Norine ID: NOR00329
  • DOI: 10.26097/nor00329
  • Family: jaspamide
  • Synonym(s): jaspamide;
  • Activity: antimicrobial, antitumor
  • Class: peptide
  • Formula: C36H45BrN4O6
  • Monoisotopic mass: 708.252248192 g/mol
  • Comment: Jaspamide showed ability to interact with actin filaments and in particular to produce structural and biophysical changes of cytoskeletal dynamics, resulting in a potent antiproliferative activity.
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
  • Type: cyclic
  • Number of monomers: 4
  • Smiles: CC3C=C(C)CC(C)C(=O)NC(C)C(=O)N(C)C(Cc1c2ccccc2([nH]c1Br))C(=O)NC(CC(=O)OC(C)C3)c4ccc(O)cc4

  • Graph inference:



  • Monomeric composition :
    1
    C9:1(4)-Me(2.4.6)-OH(8)
    2
    Ala
    3
    NMe-Br-Trp
    4
    bTyr
  • Graph representation: C9:1(4)-Me(2.4.6)-OH(8),Ala,NMe-Br-Trp,bTyr @1,3 @0,2 @1,3 @0,2

  • Atomic structure:
  • Chemical structure
    rBAN vizualisation:
  • jaspis sp.

  • Auletta sp.

  • hemiasterella minor

  • Links between organisms producing the jaspamide: jaspis sp., Auletta sp., hemiasterella minor
  • Jaspamide, a modified peptide from a Jaspis sponge, with insecticidal and antifungal activity
    Zabriskie TM, Klocke JA, Ireland CM, Journal of the American Chemical Society , 1986, 108 (11), pp. 3123-3124


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