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pholipeptin


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  • Norine ID: NOR00341
  • DOI: 10.26097/nor00341
  • Family: amphisin
  • Synonym(s): pholipeptin;
  • Activity: surfactant, antibiotic
  • Class: lipopeptide
  • Formula: C64H111N11O20
  • Monoisotopic mass: 1353.8006850470001 g/mol
  • Comment: Pholipeptin inhibited PI-PLC of human carcinoma A431 cells.
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
    • status: curated
    • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
    • view all entry history
  • Type: partial cyclic
  • Number of monomers: 12
  • Smiles: CCCCCCCC(CC(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H]1[C@H](OC(=O)C[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](NC1=O)CC(C)C)CC(C)C)CO)CC(C)C)CO)CC(C)C)[C@@H](C)CC)C(=O)O)C)O

  • Graph inference:



  • Monomeric composition :
    1
    C10:0-OH(3)
    2
    D-Leu
    3
    Asp
    4
    Thr
    5
    D-Leu
    6
    D-Leu
    7
    D-Ser
    8
    D-Leu
    9
    D-Ser
    10
    D-Leu
    11
    Ile
    12
    D-Asp
  • Graph representation: C10:0-OH(3),D-Leu,Asp,Thr,D-Leu,D-Leu,D-Ser,D-Leu,D-Ser,D-Leu,Ile,D-Asp @1 @0,2 @1,3 @2,4,11 @3,5 @4,6 @5,7 @6,8 @7,9 @8,10 @9,11 @3,10

  • Atomic structure:
    Chemical structure
  • Pseudomonas fluorescens
  • gram: negative
  • taxid: 136843 (view NCBI taxonomy browser)

  • Links between organisms producing the pholipeptin: Pseudomonas fluorescens
  • Pholipeptin, a Novel Cyclic Lipoundecapeptide fromPseudomonas fluorescens
    Ui H, Miyake T, Iinuma H, Imoto M, Naganawa H, Hattori S, Hamada M, Takeuchi T, Umezawa S, Umezawa K, The Journal of organic chemistry , 1997, Jan 10,62(1):103-108.
    DOI: 10.1021/jo9603993
    pubMed: 11671369


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