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dolastatin 10


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  • Norine ID: NOR00369
  • Family: dolastatin
  • Synonym(s): dolastatin 10;
  • Activity: antitumor
  • Class: peptide
  • Formula: C42H68N6O6S
  • Monoisotopic mass: 784.492104638 g/mol
  • Comment: dolastatin 10 is an anticancer natural product, microtubule destabilizing agent
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
    • status: curated
    • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
    • view all entry history
  • Type: linear
  • Number of monomers: 5
  • Smiles: CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@@H](CC2=CC=CC=C2)C3=NC=CS3)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)N(C)C

  • Graph inference:



  • Monomeric composition :
    1
    Dov
    2
    Val
    3
    Dil
    4
    Dap
    5
    Doe
  • Graph representation: Dov,Val,Dil,Dap,Doe @1 @0,2 @1,3 @2,4 @3

  • Atomic structure:
    Chemical structure
  • Dolabella auricularia
  • taxid: 6511 (view NCBI taxonomy browser)

  • Symploca sp. VP642
  • gram: negative
  • taxid: 162626 (view NCBI taxonomy browser)

  • Links between organisms producing the dolastatin 10: Dolabella auricularia, Symploca sp. VP642
  • Isolation of dolastatin 10 from the marine cyanobacterium Symploca species VP642 and total stereochemistry and biological evaluation of its analogue symplostatin 1
    Luesch H, Moore RE, Paul VJ, Mooberry SL, Corbett TH, Journal of natural products , 2001, Jul,64(7):907-10.
    pubMed: 11473421


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