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didemnin A


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  • Norine ID: NOR00375
  • DOI: 10.26097/nor00375
  • Family: didemnin
  • Synonym(s): didemnin A;
  • Activity: antimicrobial, antitumor, immunomodulating
  • Class: peptide
  • Formula: C49H78N6O12
  • Monoisotopic mass: 942.56777199 g/mol
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
  • Type: partial cyclic
  • Number of monomers: 7
  • Smiles: CCC(C)C2NC(=O)C(NC(=O)C(CC(C)C)NC)C(C)OC(=O)C(Cc1ccc(cc1)OC)N(C)C(=O)C3CCCN3(C(=O)C(CC(C)C)NC(=O)C(C)C(=O)C(OC(=O)CC2(O))C(C)C)

  • Graph inference:



  • Monomeric composition :
    1
    Ist
    2
    Hip
    3
    Leu
    4
    Pro
    5
    NMe-OMe-Tyr
    6
    Thr
    7
    D-NMe-Leu
  • Graph representation: Ist,Hip,Leu,Pro,NMe-OMe-Tyr,Thr,D-NMe-Leu @1,5 @0,2 @1,3 @2,4 @3,5 @0,4,6 @5

  • Atomic structure:
  • Chemical structure
    rBAN vizualisation:
  • Trididemnum solidum
  • gram:
  • synonyms:
  • taxid: 1079459 (view NCBI taxonomy browser)

  • Didemnum sp.
  • gram:
  • synonyms:
  • taxid: 107395 (view NCBI taxonomy browser)

  • Links between organisms producing the didemnin A: Trididemnum solidum, Didemnum sp.
  • Crystal and molecular structure of didemnin A, an antiviral depsipeptide
    Hossain MB, Van Der Helm D, Antel J, Sheldrick GM, Weinheimer AJ, Sanduja SK, International journal of peptide and protein research , 1996, Jan-Feb,47(1-2):20-7.
    DOI: 10.1111/j.1399-3011.1996.tb00805.x
    pubMed: 8907495
  • Natural products as probes of cell biology: 20 years of didemnin research
    Vera MD, Joullie MM, Medicinal research reviews , 2002, Mar,22(2):102-45.
    pubMed: 11857636


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