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kahalalide F

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  • Norine ID: NOR00390
  • DOI: 10.26097/nor00390
  • Family: kahalalide
  • Synonym(s): kahalalide F;
  • Activity: antibiotic, antitumor
  • Class: peptide
  • Formula: C75H124N14O16
  • Monoisotopic mass: 1476.93197399 g/mol
  • Comment: Kahalalide F alters the function of the lysosomal membrane, a mechanism that distinguishes it from all other known anti-tumour agents.
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
    • status: curated
    • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
    • view all entry history
  • Elysia rufescens
  • taxid: 380559 (view NCBI taxonomy browser)

  • Bryopsis pennata
  • taxid: 381411 (view NCBI taxonomy browser)

  • Elysia grandifolia

  • Links between organisms producing the kahalalide F: Elysia rufescens, Bryopsis pennata, Elysia grandifolia
  • Kahalalide F, a new marine-derived compound, induces oncosis in human prostate and breast cancer cells
    Suarez Y, Gonzalez L, Cuadrado A, Berciano M, Lafarga M, Munoz A, Molecular cancer therapeutics , 2003, Sep,2(9):863-72.
    pubMed: 14555705
  • Synthesis and structure determination of kahalalide F (1,2)
    Giralt E, Lopez-Macia A, Jimenez JC, Royo M, Albericio F, Journal of the American Chemical Society , 2001, Nov 21,123(46):11398-401.
    DOI: 10.1021/ja0116728
    pubMed: 11707116

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