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hemiasterlin B


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  • Norine ID: NOR00458
  • Family: hemiasterlin
  • Synonym(s): hemiasterlin B;
  • Activity: antitumor, toxin
  • Class: peptide
  • Formula: C28H43N4O4
  • Monoisotopic mass: 499.328430884 g/mol
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
    • status: putative
    • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
    • view all entry history
  • Type: linear
  • Number of monomers: 3
  • Smiles: CC(C)[C@@H](/C=C(\C)/C(=O)O)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)(C)C1=CNC2=CC=CC=C21)NC

  • Graph inference:



  • Monomeric composition :
    1
    bbMe-NMe-Trp
    2
    Val
    3
    NMe-hv-Val
  • Graph representation: bbMe-NMe-Trp,Val,NMe-hv-Val @1 @0,2 @1

  • Atomic structure:
    Chemical structure
  • Cymbastela
  • taxid: 85785 (view NCBI taxonomy browser)

  • Links between organisms producing the hemiasterlin B: Cymbastela
  • Cytotoxic peptides hemiasterlin, hemiasterlin A and hemiasterlin B induce mitotic arrest and abnormal spindle formation
    Andersen RJ, Anderson HJ, Coleman JE, Roberge M, Cancer chemotherapy and pharmacology , 1997, 39(3):223-6.
    pubMed: 8996524


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