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cyclotheonamide A


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  • Norine ID: NOR00471
  • DOI: 10.26097/nor00471
  • Family: cyclotheonamide
  • Synonym(s): cyclotheonamide A;
  • Activity: antithrombotic
  • Class: peptide
  • Formula: C36H45N9O8
  • Monoisotopic mass: 731.339109461 g/mol
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
    • status: putative
    • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
    • view all entry history
  • Type: cyclic
  • Number of monomers: 5
  • Smiles: NC(N)=NCCCC3NC(=O)C4CCCN4(C(=O)C(CNC(=O)C=CC(Cc1ccc(O)cc1)NC(=O)C(Cc2ccccc2)NC(=O)C3(=O))NC=O)

  • Graph inference:



  • Monomeric composition :
    1
    k-Arg
    2
    D-Phe
    3
    v-Tyr
    4
    NFo-Dpr
    5
    Pro
  • Graph representation: k-Arg,D-Phe,v-Tyr,NFo-Dpr,Pro @1,4 @0,2 @1,3 @2,4 @0,3

  • Atomic structure:
    Chemical structure
  • Theonella sp.
  • gram:
  • synonyms:
  • taxid: 73791 (view NCBI taxonomy browser)

  • Theonella swinhoei
  • taxid: 37505 (view NCBI taxonomy browser)

  • Links between organisms producing the cyclotheonamide A: Theonella sp., Theonella swinhoei
  • Pseudotheonamides, serine protease inhibitors from the marine sponge Theonella swinhoei
    Nakao Y, Matsunaga S, Fusetani N, Masuda A, Journal of the American Chemical Society , 1999, 121 (11), pp. 2425-2431
  • Cyclotheonamides, potent thrombin inhibitors, from a marine sponge Theonella sp.
    Matsunaga S, Fusetani N, Journal of the American Chemical Society , 1990, 112 (19), pp. 7053-7054


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