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leupeptin


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  • Norine ID: NOR00487
  • Family: leupeptin
  • Synonym(s): leupeptin;
  • Activity: protease inhibitor
  • Class: peptide
  • Formula: C20H38N6O4
  • Monoisotopic mass: 426.295453734 g/mol
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
    • status: putative
    • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
    • view all entry history
  • Type: linear
  • Number of monomers: 3
  • Smiles: CC(C)CC(NC(C)=O)C(=O)NC(CC(C)C)C(=O)NC(C=O)CCCN=C(N)N

  • Graph inference:



  • Monomeric composition :
    1
    NAc-Leu
    2
    Leu
    3
    Argal
  • Graph representation: NAc-Leu,Leu,Argal @1 @0,2 @1

  • Atomic structure:
    Chemical structure
  • Streptomyces sp.
  • gram: positive
  • taxid: 1931 (view NCBI taxonomy browser)

  • Links between organisms producing the leupeptin: Streptomyces sp.
  • Leupeptin and E-64, inhibitors of cysteine proteinases, prevent gentamicin-induced lysosomal phospholipidosis in cultured rat fibroblasts
    Montenez JP, Kishore BK, Maldague P, Tulkens PM, Toxicology letters , 1994, Sep,73(3):201-8.
    pubMed: 8091428


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