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phakellistatin 11


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  • Norine ID: NOR00533
  • DOI: 10.26097/nor00533
  • Family: phakellistatin
  • Synonym(s): phakellistatin 11;
  • Activity: antitumor
  • Class: peptide
  • Formula: C53H67N9O9
  • Monoisotopic mass: 973.506174787 g/mol
  • Comment: Phakellistatins are putative NRPS products (no synthetase genes identified)
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
    • status: putative
    • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
    • view all entry history
  • Type: cyclic
  • Number of monomers: 8
  • Smiles: CCC(C)C4NC(=O)C(Cc1ccccc1)NC(=O)C7CCCN7(C(=O)C(Cc2ccccc2)NC(=O)C6CCCN6(C(=O)C(CCC(N)=O)NC(=O)C5CCCN5(C(=O)C(Cc3ccccc3)NC4(=O))))

  • Graph inference:



  • Monomeric composition :
    1
    Pro
    2
    Phe
    3
    Pro
    4
    Phe
    5
    Ile
    6
    Phe
    7
    Pro
    8
    Gln
  • Graph representation: Pro,Phe,Pro,Phe,Ile,Phe,Pro,Gln @1,7 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @0,6

  • Atomic structure:
    Chemical structure
  • Phakellia sp.

  • Links between organisms producing the phakellistatin 11: Phakellia sp.
  • Antineoplastic agents, 325. Isolation and structure of the human cancer cell growth inhibitory cyclic octapeptides phakellistatin 10 and 11 from Phakellia sp
    Pettit GR, Boyd MR, Cerny RL, Doubek DL, Tackett LP, Schmidt JM, Williams MD, Tan R, Ichihara Y, Hooper JN, Journal of natural products , 1995, Jun,58(6):961-5.
    DOI: 10.1021/np50120a025
    pubMed: 7673945


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