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microsclerodermin I


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  • Norine ID: NOR00559
  • DOI: 10.26097/nor00559
  • Family: microsclerodermin
  • Synonym(s): microsclerodermin I;
  • Activity: antimicrobial, antitumor
  • Class: peptide
  • Formula: C46H56N8O12
  • Monoisotopic mass: 912.401769296 g/mol
  • Comment: Microsclerodermins are putative NRPS products (no synthetase genes identified)
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
    • status: putative - change status to non-NRP (Norine validators only)
    • last modification date: 2018-09-12 by Mickael Chevalier [Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
    • view all entry history
  • Type: cyclic
  • Number of monomers: 6
  • Monomeric composition :
    1
    C12:3(7.9.11)-Me(6.10)-OH(2.4.5)-NH2(3)-Ph(12)
    2
    Pyr
    3
    NMe-Gly
    4
    dh-Trp
    5
    Gly
    6
    OH-4Abu
  • Graph representation: C12:3(7.9.11)-Me(6.10)-OH(2.4.5)-NH2(3)-Ph(12),Pyr,NMe-Gly,dh-Trp,Gly,OH-4Abu @1,5 @0,2 @1,3 @2,4 @3,5 @0,4

  • Atomic structure:
  • Peptide's atomic structure image is not available because smiles is not present.

  • Microscleroderma sp.

  • Links between organisms producing the microsclerodermin I: Microscleroderma sp.
  • Microsclerodermins F-I, antitumor and antifungal cyclic peptides from the lithistid sponge Microscleroderma sp.
    Faulkner DJ, Qureshi A, Colin PL, Tetrahedron , 2000, 56 (23), pp. 3679-3685


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