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malformin C


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  • Norine ID: NOR00630
  • DOI: 10.26097/nor00630
  • Family: malformin
  • Synonym(s): malformin C;
  • Activity: antitumor, toxin
  • Class: peptide
  • Formula: C23H39N5O5S2
  • Monoisotopic mass: 529.239260783 g/mol
  • Comment: The two cysteins have a disulfide bridge between them.
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
    • status: curated
    • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
    • view all entry history
  • Type: other
  • Number of monomers: 5
  • Smiles: CC(C)CC1NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C2CSSCC(NC1(=O))C(=O)N2)C(C)C

  • Graph inference:



  • Monomeric composition :
    1
    D-Cys
    2
    D-Cys
    3
    Val
    4
    D-Leu
    5
    Leu
  • Graph representation: D-Cys,D-Cys,Val,D-Leu,Leu @1,1,4 @0,0,2 @1,3 @2,4 @0,3

  • Atomic structure:
  • Chemical structure
    rBAN vizualisation:
  • Aspergillus niger
  • taxid: 5061 (view NCBI taxonomy browser)

  • Links between organisms producing the malformin C: Aspergillus niger
  • Structure of malformin B, a phytotoxic metabolite produced by Aspergillus niger
    Sugawara F, Kim KW, Yoshida S, Takahashi N, Curtis RW, Murofushi N, Bioscience, biotechnology, and biochemistry , 1993, May,57(5):787-91.
    DOI: 10.1271/bbb.57.787
    pubMed: 7763777
  • Fungal malformins inhibit bleomycin-induced G2 checkpoint in Jurkat cells
    Tomoda H, Omura S, Fukuda T, Hagimori K, Hasegawa Y, Biological and pharmaceutical bulletin , 2007, Aug,30(8):1379-83.
    DOI: 10.1248/bpb.30.1379
    pubMed: 17666789


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