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A21978C3


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  • Norine ID: NOR00759
  • Family: daptomycin
  • Synonym(s): A21978C3;
  • Activity: antibiotic
  • Class: lipopeptide
  • Formula: C75H107N17O26
  • Monoisotopic mass: 1661.757316681 g/mol
  • Comment: A21978C is a complex of lipopeptides which differ on their fatty acid moiety. It is used to treat complicated skin infections.
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
    • status: curated
    • last modification date: 2008-07-31 by Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
    • view all entry history
  • Streptomyces roseosporus
  • gram: positive
  • synonyms: Streptomyces filamentosus,Streptomyces venezuelae subsp. roseospori,Streptomyces roseisporus
  • taxid: 67294 (view NCBI taxonomy browser)

  • Links between organisms producing the A21978C3: Streptomyces roseosporus
  • A21978C, a complex of new acidic peptide antibiotics: isolation, chemistry, and mass spectral structure elucidation
    Debono M, Barnhart M, Carrell CB, Hoffmann JA, Occolowitz JL, Abbott BJ, Fukuda DS, Hamill RL, Biemann K, Herlihy WC, The Journal of antibiotics , 1987, Jun,40(6):761-77.
    pubMed: 3610833
  • Daptomycin biosynthesis in Streptomyces roseosporus: cloning and analysis of the gene cluster and revision of peptide stereochemistry
    Miao V, Coeffet-Legal MF, Brian P, Brost R, Penn J, Whiting A, Martin S, Ford R, Parr I, Bouchard M, Silva CJ, Wrigley SK, Baltz RH, Microbiology , 2005, May,151(Pt 5):1507-23.
    pubMed: 15870461
  • Biosynthesis and genetic engineering of lipopeptide antibiotics related to daptomycin
    Baltz RH, Current topics in medicinal chemistry , 2008, 8(8):618-38
    pubMed: 18473888


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