Norine

home > NRP > norine

galacardin B


Get HTML  Get XML  Get Json  Import model in MyNorine  Modify

  • Norine ID: NOR00934
  • Family: galacardin
  • Synonym(s): galacardin B;
  • Activity: antibiotic
  • Class: glycopeptide
  • Formula: C95H111Cl2N9O41
  • Monoisotopic mass: 2103.625449519 g/mol
  • Comment: They showed strong antimicrobial activity against Gram-positive bacteria and also showed excellent in vivo protective activity against Staphylococcus aureus infection in mice. Two bonds of the central Hpg are due to oxidative ring closure reactions.
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
    • status: curated
    • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
    • view all entry history
  • Type: other
  • Number of monomers: 13
  • Smiles: CC1C(C(CC(O1)OC2C(C(C(OC2OC3=C4C=C5C=C3OC6=C(C=C(C=C6)C(C7C(=O)NC(C8=CC(=CC(=C8C9=C(C=CC(=C9)C(C(=O)N7)NC(=O)C5NC(=O)C(NC(=O)C(C(C1=CC=C(O4)C=C1)OC1C(C(C(C(O1)CO)O)O)O)NC(=O)C(C1=CC=C(C=C1)OC1C(C(C(C(O1)C)OC1C(C(C(C(O1)CO)O)O)O)O)O)NC)C1=CC(=C(C=C1)O)Cl)O)O)O)C(=O)O)OC1CC(C(C(O1)C)O)N)Cl)CO)O)O)N)O

  • Graph inference:



  • Monomeric composition :
    1
    NMe-Hpg
    2
    D-Gal
    3
    Rha
    4
    bOH-Tyr
    5
    D-Man
    6
    Hpg
    7
    Cl-Hpg
    8
    bOH-Cl-Tyr
    9
    Dhpg
    10
    Hpg
    11
    Ria
    12
    Ria
    13
    D-Glc
  • Graph representation: NMe-Hpg,D-Gal,Rha,bOH-Tyr,D-Man,Hpg,Cl-Hpg,bOH-Cl-Tyr,Dhpg,Hpg,Ria,Ria,D-Glc @3,1 @0,2 @1 @5,6,4,0 @3 @3,6,7,9,10 @3,5 @5,9,8,11 @9,7 @5,7,8 @5,12 @7 @10

  • Atomic structure:
    Chemical structure
  • Saccharothrix
  • gram: positive
  • taxid: 2071 (view NCBI taxonomy browser)

  • Links between organisms producing the galacardin B: Saccharothrix
  • Galacardins A and B, new glycopeptide antibiotics
    Nakamura T, Inukai M, Katayama T, Takahashi S, Takeuchi M, Enokita R, Sakaida Y, Haruyama H, The Journal of antibiotics , 1992, Mar,45(3):297-305.
    pubMed: 1577657


back Return to annotations search