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atroviridin A


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  • Norine ID: NOR00961
  • DOI: 10.26097/nor00961
  • Family: atroviridin
  • Synonym(s): atroviridin A;
  • Activity: antibiotic
  • Class: peptaibol
  • Formula: C92H151N23O24
  • Monoisotopic mass: 1962.130232875 g/mol
  • Comment: They showed antimicrobial activity against Gram-positive bacteria and phytopathogenic fungi, and exhibited significant cytotoxicity to human cancer cell lines in vitro. Atroviridins showed significant membrane-perturbing activity responsible to their antibiotic action.
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
    • status: curated
    • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
    • view all entry history
  • Type: linear
  • Number of monomers: 20
  • Smiles: C[C@@H](C(=N[C@@H](CCC(=N)O)C(=NC(C)(C)C(=N[C@@H](C(C)C)C(=NC(C)(C)C(=NCC(=N[C@@H](CC(C)C)C(=NC(C)(C)C(=O)N1CCC[C@H]1C(=N[C@@H](C(C)C)C(=NC(C)(C)C(=NC(C)(C)C(=N[C@@H](CCC(=N)O)C(=N[C@@H](CCC(=N)O)C(=N[C@@H](CC2=CC=CC=C2)CO)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C(C(C)(C)N=C([C@H](C)N=C(C(C)(C)N=C([C@@H]3CCCN3C(=O)C(C)(C)N=C(C)O)O)O)O)O

  • Graph inference:



  • Monomeric composition :
    1
    Ac-Aib
    2
    Pro
    3
    Aib
    4
    Ala
    5
    Aib
    6
    Ala
    7
    Gln
    8
    Aib
    9
    Val
    10
    Aib
    11
    Gly
    12
    Leu
    13
    Aib
    14
    Pro
    15
    Val
    16
    Aib
    17
    Aib
    18
    Gln
    19
    Gln
    20
    Pheol
  • Graph representation: Ac-Aib,Pro,Aib,Ala,Aib,Ala,Gln,Aib,Val,Aib,Gly,Leu,Aib,Pro,Val,Aib,Aib,Gln,Gln,Pheol @1 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @8,10 @9,11 @10,12 @11,13 @12,14 @13,15 @14,16 @15,17 @16,18 @17,19 @18

  • Atomic structure:
    Chemical structure
  • Trichoderma atroviride
  • taxid: 63577 (view NCBI taxonomy browser)

  • Links between organisms producing the atroviridin A: Trichoderma atroviride
  • Atroviridins A-C and neoatroviridins A-D, novel peptaibol antibiotics produced by Trichoderma atroviride F80317. I. Taxonomy, fermentation, isolation and biological activities
    Oh SU, Yun BS, Lee SJ, Kim JH, Yoo ID, The Journal of antibiotics , 2002, Jun,55(6):557-64.
    DOI: 10.7164/antibiotics.55.557
    pubMed: 12195961


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