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Leu1-zervamicin


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  • Norine ID: NOR01093
  • DOI: 10.26097/nor01093
  • Family: zervamicin
  • Synonym(s): Leu1-zervamicin;
  • Activity: antibiotic
  • Class: peptaibol
  • Formula: C85H140N18O22
  • Monoisotopic mass: 1765.0389582540001 g/mol
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
    • status: curated
    • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
    • view all entry history
  • Type: linear
  • Number of monomers: 16
  • Smiles: CCC(C)C(NC(=O)C(CC(C)C)NC(C)=O)C(=O)NC(CCC(N)=O)C(=O)NC(C)(CC)C(=O)NC(C(C)CC)C(=O)NC(C(C)O)C(=O)NC(C)(C)C(=O)NC(CC(C)C)C(=O)NC(C)(C)C(=O)N4CC(O)CC4(C(=O)NC(CCC(N)=O)C(=O)NC(C)(C)C(=O)N3CC(O)CC3(C(=O)NC(C)(C)C(=O)N2CCCC2(C(=O)NC(CO)Cc1ccccc1)))

  • Graph inference:



  • Monomeric composition :
    1
    NAc-Leu
    2
    Ile
    3
    Gln
    4
    D-Ival
    5
    Ile
    6
    Thr
    7
    Aib
    8
    Leu
    9
    Aib
    10
    4OH-Pro
    11
    Gln
    12
    Aib
    13
    4OH-Pro
    14
    Aib
    15
    Pro
    16
    Pheol
  • Graph representation: NAc-Leu,Ile,Gln,D-Ival,Ile,Thr,Aib,Leu,Aib,4OH-Pro,Gln,Aib,4OH-Pro,Aib,Pro,Pheol @1 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @8,10 @9,11 @10,12 @11,13 @12,14 @13,15 @14

  • Atomic structure:
  • Chemical structure
    rBAN vizualisation:
  • Emericellopsis salmosynnemata
  • taxid: 118885 (view NCBI taxonomy browser)

  • Links between organisms producing the Leu1-zervamicin: Emericellopsis salmosynnemata
  • Crystal structure of [Leu1]zervamicin, a membrane ion-channel peptide: implications for gating mechanisms
    Flippen-Anderson JL, Karle IL, Balaram P, Agarwalla S, Proceedings of the National Academy of Sciences of the United States of America , 1991, Jun 15,88(12):5307-11.
    DOI: 10.1073/pnas.88.12.5307
    pubMed: 1711227


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